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Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning

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العنوان: Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning
المؤلفون: Susanna Kaisto, Antti M. Salo, Kirsten Y. Renkema, Leonardo D. Garma, Wout F.J. Feitz, Ernie M.H.F. Bongers, Ilkka Miinalainen, Elisavet Tika, Johanna Myllyharju, André H. Juffer, Ilkka Pietilä, Nine V A M Knoers, Albertien M. van Eerde, Seppo Vainio, Renata Prunskaite-Hyyryläinen
المصدر: PLoS ONE, Vol 11, Iss 1, p e0147171 (2016)
PLoS ONE, 11(1):e0147171. PUBLIC LIBRARY SCIENCE
PLoS ONE [E], 11(1). Public Library of Science
PLoS ONE
PLoS One, 11, 1
PLoS One, 11
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
مصطلحات موضوعية: Pathology, Organogenesis, Developmental Signaling, Biochemistry, Immunoenzyme Techniques, Mice, Cell Signaling, Laminin, Biochemical Simulations, Child, lcsh:Science, Cells, Cultured, In Situ Hybridization, Cultured, Hyperplasia, Kidney Tubules, Cellular Structures and Organelles, Kidney Tubules, Collecting/metabolism, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], medicine.medical_specialty, Cells, Knockout, Wnt-5a Protein, 03 medical and health sciences, Genetics, Humans, RNA, Messenger, Kidney Tubules, Collecting, Vesico-Ureteral Reflux, Embryos, lcsh:R, Biology and Life Sciences, Proteins, Computational Biology, Epithelial Cells, medicine.disease, Wnt Proteins, body regions, 030104 developmental biology, Urogenital Abnormalities, Mutation, Messenger/genetics, lcsh:Q, Ureter, Organism Development, Developmental Biology, 0301 basic medicine, RNA, Messenger/genetics, Embryology, Protein Conformation, Gene Expression, lcsh:Medicine, Basement Membrane, Type IV collagen, Wnt4 Protein, Ureter/embryology, Medicine and Health Sciences, Morphogenesis, Non-U.S. Gov't, Mice, Knockout, Kidney, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Research Support, Non-U.S. Gov't, Vesico-Ureteral Reflux/physiopathology, Hypoplasia, Extracellular Matrix, medicine.anatomical_structure, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Embryo, Mammalian/cytology, Embryo, Ureteric bud, embryonic structures, Urogenital Abnormalities/physiopathology, Female, Anatomy, Research Article, Signal Transduction, Adolescent, Mutation/genetics, Biology, Research Support, Real-Time Polymerase Chain Reaction, Epithelial Cells/cytology, Wnt4 Protein/physiology, medicine, Journal Article, Animals, Mammalian/cytology, Basement membrane, Basement Membrane/metabolism, Wnt Proteins/chemistry, Kidneys, Renal System, Cell Biology, Embryo, Mammalian, Molecular biology, Epithelium, biology.protein, RNA, Collecting/metabolism, sense organs, Collagens
الوصف: Contains fulltext : 171962.PDF (Publisher’s version ) (Open Access) The Wnts can be considered as candidates for the Congenital Anomaly of Kidney and Urinary Tract, CAKUT diseases since they take part in the control of kidney organogenesis. Of them Wnt5a is expressed in ureteric bud (UB) and its deficiency leads to duplex collecting system (13/90) uni- or bilateral kidney agenesis (10/90), hypoplasia with altered pattern of ureteric tree organization (42/90) and lobularization defects with partly fused ureter trunks (25/90) unlike in controls. The UB had also notably less tips due to Wnt5a deficiency being at E15.5 306 and at E16.5 765 corresponding to 428 and 1022 in control (p
وصف الملف: application/pdf; image/pdf
اللغة: English
تدمد: 1932-6203
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2104479b07cea20f1ec3aa04734d751
http://europepmc.org/articles/PMC4721645?pdf=render
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....a2104479b07cea20f1ec3aa04734d751
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19326203