RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma
| العنوان: | RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma |
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| المؤلفون: | Massimo Santoro, Fulvio Basolo, Aldo Pinchera, Luca Pollina, Furio Pacini, Carmen Monaco, Paolo Miccoli, Gennaro Chiappetta, Alfredo Fusco, Eleonora Molinaro, Rossella Elisei, Marco Capezzone, Laura Agate |
| المساهمون: | F., Basolo, E., Molinaro, L., Agate, A., Pinchera, L., Pollina, G., Chiappetta, C., Monaco, Santoro, Massimo, Fusco, Alfredo, P., Miccoli, R., Elisei, M., Capezzone, F., Pacini |
| المصدر: | Scopus-Elsevier |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Papillary, Thyroid Gland, Proto-Oncogene Mas, Papillary thyroid cancer, Pathogenesis, Endocrinology, Drosophila Proteins, Child, Regulation of gene expression, Aged, 80 and over, Thyroid, General Medicine, genetics, Humans, Immunohistochemistry, Male, Middle Aged, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ret, Receptor Protein-Tyrosine Kinases, Thyroid Gland, Middle Aged, Prognosis, Immunohistochemistry, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Proto-Oncogene Proteins c-ret, Female, Adult, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, medicine.medical_specialty, Adolescent, Thyroid carcinoma, Internal medicine, Proto-Oncogene Proteins, medicine, Carcinoma, Humans, Thyroid Neoplasms, neoplasms, diagnosis/metabolism/pathology, Child, Drosophila Proteins, Female, Follow-Up Studies, Gene Expression Regulation, metabolism/pathology, Thyroid Neoplasm, Aged, Neoplastic, business.industry, Receptor Protein-Tyrosine Kinases, medicine.disease, Carcinoma, Papillary, Adolescent, Adult, Aged, Aged, 80 and over, Biological Markers, Carcinoma, diagnosis/metabolism/pathology, business, Biomarkers, Follow-Up Studies |
| الوصف: | BACKGROUND: RET proto-oncogene rearrangements (RET/PTC) are causative events in the pathogenesis of a subset of papillary thyroid cancer (PTC). The prevalence of RET/PTC varies in different countries and according to specific clinical features: it is higher after radiation exposure and it is claimed to be higher in young patients. Conflicting results are reported regarding the prognostic role of RET/PTC activation. OBJECTIVE: To investigate the prognostic meaning of RET/PTC rearrangement on the long term outcome of PTC. METHODS: We have studied the expression of the RET encoded protein in 127 papillary thyroid carcinomas by immunohistochemistry using a polyclonal antibody against the tyrosine-kinase domain of the RET protein. These cases have been collected during 1970-1985, and have a mean (+/-S.D.) period of follow-up of 18.6+/-3.7 years (range 12-27 years). The results have been compared with the patients' outcome. RESULTS: The tyrosine-kinase domain of RET was expressed in 82 (64.6%) papillary carcinomas. Among them, RET was highly expressed in 65 (51.2%) cases and moderately expressed in 17 (13.4%). RET expression was absent in 45 (35.4%) cases. No correlation was found between RET expression and other parameters such as sex, age at diagnosis, tumor class and histological variant. Follow-up analysis showed no influence of RET expression on patients' outcome. By multivariate analysis, age (>45 years) and tumor class IV, but not sex and RET expression were adverse prognostic indicators of death. CONCLUSION: In conclusion, our analysis indicates that RET expression is frequently found in PTC, and has no influence on tumor outcome. |
| وصف الملف: | STAMPA |
| تدمد: | 0804-4643 1970-1985 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a228d114490f4b9efc6288cadc2941b2 https://pubmed.ncbi.nlm.nih.gov/11720878 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a228d114490f4b9efc6288cadc2941b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08044643 19701985 |
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