Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria
| العنوان: | Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria |
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| المؤلفون: | Young Sun Hwang, Seok Kyun Yun, Jongsung Lee, Youn Hwa Nho |
| المصدر: | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE(17) BMC Complementary and Alternative Medicine |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, Dental plaque bacteria (DPB), Anti-Inflammatory Agents, Lipopolysaccharide (LPS), Osteoclasts, Pharmacology, Mice, Gingivitis, 0302 clinical medicine, biology, General Medicine, Anti-Bacterial Agents, Terminalia chebula, medicine.anatomical_structure, RANKL, Terminalia, Osteoclast, Cytokines, medicine.symptom, Research Article, Ethanol extract of Terminalia chebula (EETC), medicine.medical_specialty, Periodontitis, Inflammation, Dental Plaque, Dental plaque, Dinoprostone, Bone resorption, Proinflammatory cytokine, 03 medical and health sciences, medicine, Animals, Bone Resorption, Periodontal Diseases, Mouth, Osteoblasts, Bacteria, Plant Extracts, business.industry, RANK Ligand, 030206 dentistry, medicine.disease, RAW 264.7 Cells, 030104 developmental biology, Complementary and alternative medicine, Cyclooxygenase 2, biology.protein, business, Peptide Hydrolases, Phytotherapy |
| الوصف: | Background: The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption. Methods: The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays. Results: EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption. Conclusions: EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease. |
| تدمد: | 1472-6882 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2747b1f5b9d863d3dd3ee6fa975a1ee https://doi.org/10.1186/s12906-017-1619-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a2747b1f5b9d863d3dd3ee6fa975a1ee |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14726882 |
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