A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide
| العنوان: | A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide |
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| المؤلفون: | Ivana Di Bari, Aurore Fraix, Éva Fenyvesi, Vladimir Kirejev, Salvatore Sortino, Mimimorena Seggio, Marica B. Ericson, Milo Malanga |
| المصدر: | Biomaterials Science. 7:2272-2276 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Polymers, Cyclodextrins, Nitric Oxide, medicine.medical_treatment, Biomedical Engineering, Photodynamic therapy, 02 engineering and technology, Nitric Oxide, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, medicine, Fluorescence microscope, Moiety, General Materials Science, Photosensitizer, Fluorescein, Fluorescent Dyes, Drug Carriers, Cyclodextrins, Chemistry, beta-Cyclodextrins, Water, 021001 nanoscience & nanotechnology, Fluorescence, Drug Liberation, Fluorescein-5-isothiocyanate, Solubility, 0104 chemical sciences, Squamous carcinoma, Drug delivery, Biophysics, 0210 nano-technology |
| الوصف: | We report herein on a novel water-soluble β-cyclodextrin-branched polymer covalently integrating a fluorescein moiety and a nitric oxide (NO) photodonor within its macromolecular skeleton. Photoexcitation with visible light induces the parallel activation of the two chromophores, which results in the green fluorescence emission suitable for imaging accompanied by NO release for therapy. In fact, this polymer internalizes in squamous carcinoma cancer cells in vitro, visualized by fluorescence microscopy, and induces cell mortality as result of the NO photo-decaging. The non-covalent drug delivery capability of this new material is also demonstrated using a hydrophobic photosensitizer for photodynamic therapy as a probe. |
| تدمد: | 2047-4849 2047-4830 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28e3f135e5b8cad9d427ffdd20a41f3 https://doi.org/10.1039/c9bm00395a |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a28e3f135e5b8cad9d427ffdd20a41f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474849 20474830 |
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