The influence of preoperative biopsy on the surgical method in breast cancer patients: a single-center experience of 3,966 cases in China
| العنوان: | The influence of preoperative biopsy on the surgical method in breast cancer patients: a single-center experience of 3,966 cases in China |
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| المؤلفون: | Jichun Zhou, Linbo Wang, Wenhe Zhao, Jida Chen, Lidan Jin, Wenxian Hu, Qun Wei, Mingjun Dong, Rongyue Teng |
| المصدر: | Gland Surg |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Breast biopsy, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Sentinel lymph node, medicine.disease, 030218 nuclear medicine & medical imaging, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Fine-needle aspiration, Breast cancer, 030220 oncology & carcinogenesis, Biopsy, medicine, Original Article, Surgery, Radiology, Stage (cooking), Segmental resection, business |
| الوصف: | Background The National Surgical Adjuvant Breast and Bowel Project (NSABP) B32 trial reported that the detection rate of sentinel lymph nodes by core needle biopsy (CNB) is higher than that by segmental resection. However, there are few reports regarding the detection rate of sentinel lymph nodes by vacuum-assisted breast biopsy (VABB). Therefore, we analyzed the impact of preoperative biopsy methods on the surgical modes of 3,966 patients with breast cancer in our center. Methods In total, 3,966 female breast cancer patients [clinical tumor node metastasis (TNM) stage I-III] were enrolled in this study. Preoperative pathological diagnosis methods included fine needle aspiration (FNA) biopsy, CNB, excision biopsy, and VABB. According to the time of diagnosis. The data were analysis by chi square test, variance analysis and the Kaplan-Meier time series in SPSS 22.0. Results There was a decrease in the number of patients that underwent excision biopsy (7.3% to 2.7%) and intraoperative freezing (89.4% to 28.9%) over time, while CNB exhibited an increasing trend (1.6% to 55.3%). The positive rates of VABB, CNB, excision biopsy, and FNA were 99.5%, 97.1%, 97.9%, and 82.2%, respectively, and the false negative rates were 0%, 1.8%, 0.34%, and 8.9%, respectively. The overall breast-conserving rate was 36.7%, while the breast-conserving rate for VABB was 57.1%. The axillary sentinel lymph node biopsy rate of cN0 patients was 48.3%, and the intraoperative frozen group (36.7%) and excision biopsy group (39.5%) were lower than the CNB (57.1%) and VABB (77.9%) groups. Until December 2019, there were 350 cases with tumor recurrence or metastasis. The methods of biopsy were not correlated to the cumulative survival time. Conclusions Changes to the diagnosis and treatment of breast cancer has a profound impact on the method of tumor biopsy. VABB biopsy offers advantages such as accurate diagnosis, a greater volume of tissue taken at one time, minimally invasive and repeatable, and does not affect the surgical approach and prognosis of patients. It will gradually become the primary method of preoperative pathological evaluation of breast cancer. |
| تدمد: | 2227-8575 2227-684X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28eeebd73fe2dd30bd9d7db6199f592 https://doi.org/10.21037/gs-21-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a28eeebd73fe2dd30bd9d7db6199f592 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22278575 2227684X |
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