Feline immunodeficiency virus infection: plasma, but not peripheral blood mononuclear cell virus titer is influenced by zidovudine and cyclosporine
| العنوان: | Feline immunodeficiency virus infection: plasma, but not peripheral blood mononuclear cell virus titer is influenced by zidovudine and cyclosporine |
|---|---|
| المؤلفون: | H. S. Park, R. B. Cope, Wayne K. Greene, Joanne Meers, Wayne F. Robinson, G. M. del Fierro |
| المصدر: | Archives of Virology. 132:67-81 |
| بيانات النشر: | Springer Science and Business Media LLC, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Male, Feline immunodeficiency virus, Genes, Viral, viruses, Molecular Sequence Data, Immunodeficiency Virus, Feline, Peripheral blood mononuclear cell, Virus, Zidovudine, Immune system, Feline Acquired Immunodeficiency Syndrome, Virology, Blood plasma, medicine, Animals, Amino Acid Sequence, Cells, Cultured, biology, RNA-Directed DNA Polymerase, General Medicine, biology.organism_classification, Titer, Immunology, Cats, Cyclosporine, Leukocytes, Mononuclear, Female, Viral disease, medicine.drug |
| الوصف: | The plasma and peripheral blood mononuclear cell (PBMC) titer of feline immunodeficiency virus (FIV) in experimentally infected cats was assessed following administration of either zidovudine or cyclosporine. Treatments were begun 24 h post infection (p.i.) and continued for 4 weeks. Zidovudine treatment did not prevent establishment of infection with FIV, but plasma virus titers were significantly lower than controls at 2 weeks p.i. This reduction of plasma virus titer by zidovudine was not maintained at subsequent sampling times. Similarly, cyclosporine treatment initially lowered plasma virus titers at 2 weeks p.i., but at 4 weeks p.i. the plasma virus titers in cyclosporine-treated cats were significantly higher than in the untreated group. In the untreated group, plasma virus titers declined rapidly to an undetectable level by 14 weeks p.i. Neither zidovudine or cyclosporine treatment significantly influenced the titer of FIV in PBMCs. In all groups (untreated, zidovudine and cyclosporine) the titers in PBMC were high for the duration of the experiment. The decline in plasma virus titers in immunocompetent cats combined with the effect of cyclosporine on plasma titers strongly suggests that the immune system plays a major role in clearing FIV from plasma. In contrast, it appears that the immune response has little impact on PBMC virus titers. This shows that for complete assessment of antiviral agents, both cell-free and cell-associated virus titers must be examined. We also suggest that the limitation of viral titers in PBMC may be of critical importance in the control of lentiviral infection. |
| تدمد: | 1432-8798 0304-8608 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cad35b82ea3390ed6e6af4814a4fe7 https://doi.org/10.1007/bf01309844 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a2cad35b82ea3390ed6e6af4814a4fe7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14328798 03048608 |
|---|