Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy
| العنوان: | Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy |
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| المؤلفون: | Jian Zhou, Hao Li, Jie Tian, Fan Yang, Yamin Mao, Chongwei Chi, Jun Wang |
| المصدر: | Journal of Thoracic Disease. 8:1841-1845 |
| بيانات النشر: | AME Publishing Company, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Thoracoscope, business.industry, Normal tissue, 030204 cardiovascular system & hematology, medicine.disease, eye diseases, Surgery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Bolus (medicine), chemistry, Pneumothorax, Male patient, 030220 oncology & carcinogenesis, medicine, Video assisted, Surgical Technique, business, Nuclear medicine, Lung tissue, Indocyanine green |
| الوصف: | Failure to identify all the possible bullous lesions was considered an important reason for the higher recurrence rate after the VATS bullectomy. We applied the latest near-infrared (NIR) thoracoscope with indocyanine green (ICG) to detect bullous lesions for patients with spontaneous pneumothorax. Two male patients with spontaneous pneumothorax and poorly identified bullae intraoperatively were included in this pilot study. An NIR thoracoscope with two different doses of ICG injection (0.2 and 0.6 mg/kg) was used to detect bullous lesions during VATS bullectomy. Partial lung resections of the bullous lesions were performed under syncretic mode. Data was managed with ImageJ software. No procedure-related complications were observed. The fluorescent signal was detected in normal lung tissue 10.5 seconds (mean, 10-11 seconds) after the ICG bolus, and lasted up to 525 seconds (mean, 480-570 seconds). The bullous lesions showed an obviously decreased fluorescent densities comparing to adjacent normal tissue. At the dosage of 0.6 mg/kg, ICG emits sufficient fluorescence to demonstrate the precise border of bullae, with the max SBR of 6.32. All resected specimens were confirmed as bullous lesions microscopically. NIR thoracoscope with intravenous ICG is a safe, accurate and real-time method to detect bullous lesions of lung tissue difficult to be found under normal light in human subjects.NCT02611245 (https://register.clinicaltrials.gov/). |
| تدمد: | 2077-6624 2072-1439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31323b5154e979d9f614ec010004039 https://doi.org/10.21037/jtd.2016.06.02 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a31323b5154e979d9f614ec010004039 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20776624 20721439 |
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