NO donors and NO delivery methods for controlling biofilms in chronic lung infections
| العنوان: | NO donors and NO delivery methods for controlling biofilms in chronic lung infections |
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| المؤلفون: | Yu-ming Cai, Ying-Dan Zhang, Liang Yang |
| المصدر: | Applied Microbiology and Biotechnology |
| بيانات النشر: | Springer Berlin Heidelberg, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.drug_class, Antibiotics, medicine.disease_cause, Applied Microbiology and Biotechnology, Cystic fibrosis, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, medicine, Humans, Nitric Oxide Donors, Pseudomonas Infections, Lung, 030304 developmental biology, Primary ciliary dyskinesia, 0303 health sciences, COPD, 030306 microbiology, business.industry, Pseudomonas aeruginosa, Biofilm, General Medicine, Mini-Review, medicine.disease, Anti-Bacterial Agents, Chronic lung infection, chemistry, Biofilms, Immunology, Respiratory epithelium, business, Biotechnology |
| الوصف: | Abstract Nitric oxide (NO), the highly reactive radical gas, provides an attractive strategy in the control of microbial infections. NO not only exhibits bactericidal effect at high concentrations but also prevents bacterial attachment and disperses biofilms at low, nontoxic concentrations, rendering bacteria less tolerant to antibiotic treatment. The endogenously generated NO by airway epithelium in healthy populations significantly contributes to the eradication of invading pathogens. However, this pathway is often compromised in patients suffering from chronic lung infections where biofilms dominate. Thus, exogenous supplementation of NO is suggested to improve the therapeutic outcomes of these infectious diseases. Compared to previous reviews focusing on the mechanism of NO-mediated biofilm inhibition, this review explores the applications of NO for inhibiting biofilms in chronic lung infections. It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods. Key points • The relationship between abnormal NO levels and biofilm development in lungs • The antibiofilm property of NO and current applications in lungs • Potential NO delivery methods and research directions in the future |
| اللغة: | English |
| تدمد: | 1432-0614 0175-7598 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3253dd96671bc7b5adfcec806c53cef http://europepmc.org/articles/PMC8140970 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a3253dd96671bc7b5adfcec806c53cef |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320614 01757598 |
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