The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer
| العنوان: | The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer |
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| المؤلفون: | Bi Ling Chen, Mingming Zhang, Ruonan Zhang, Wenzheng Zhang, Ting Jin, Zuyi Yang, Xingxing Huang, Xia Ding, Ting Duan, Jiao Feng, Xinbing Sui, Xiaying Chen, Ting Pan, Tian Xie, Lili Yan, Yu Xiang |
| المصدر: | Genes & Diseases Genes and Diseases, Vol 8, Iss 6, Pp 781-797 (2021) |
| بيانات النشر: | Chongqing Medical University, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Medicine (General), Carcinogenesis, Urinary system, Inflammation, Review Article, Pathogenesis, QH426-470, medicine.disease_cause, urologic and male genital diseases, Biochemistry, 03 medical and health sciences, R5-920, 0302 clinical medicine, Genetics, medicine, Inflammatory molecules, Neoplastic transformation, Microbiome, Molecular Biology, Genetics (clinical), Bladder cancer, Progression, business.industry, Cell Biology, medicine.disease, 030104 developmental biology, Urinary microbiome, 030220 oncology & carcinogenesis, Cancer research, medicine.symptom, business, Inflammatory microenvironment |
| الوصف: | Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies, including bladder cancer. This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment. Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of inflammatory molecules and signals. Recently, it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer, which can be mediated through the stimulation of chronic inflammation. In effect, the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer. In other words, chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer. Here, we provide a detailed and comprehensive account of the link between chronic inflammation, the microbiome and bladder cancer. Finally, we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment. |
| اللغة: | English |
| تدمد: | 2352-3042 2352-4820 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33a71102c7a6fab2bc91432a924e0ea http://europepmc.org/articles/PMC8427242 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a33a71102c7a6fab2bc91432a924e0ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523042 23524820 |
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