Tuberculosis in Older Adults: Seattle and King County, Washington
| العنوان: | Tuberculosis in Older Adults: Seattle and King County, Washington |
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| المؤلفون: | Christopher Spitters, Masahiro Narita, David J. Horne, Sanju Bhattarai, Katelynne Gardner Toren, Monica Pecha |
| المصدر: | Clinical Infectious Diseases. |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Washington, 0301 basic medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, Tuberculosis, 030106 microbiology, Antitubercular Agents, Patient characteristics, Disease, 03 medical and health sciences, 0302 clinical medicine, Older patients, Humans, Medicine, 030212 general & internal medicine, Adverse effect, Tuberculosis, Pulmonary, Aged, business.industry, Pyrazinamide, medicine.disease, Infectious Diseases, Treatment interruption, business, Tb treatment, medicine.drug |
| الوصف: | BACKGROUND In the United States, tuberculosis (TB) incidence rates are highest among adults aged ≥65 years. We performed this study to evaluate outcomes of older patients undergoing treatment for TB disease, including the frequency of adverse events related to TB treatment. METHODS This study evaluated adult patients who were diagnosed with pulmonary TB from 2009 to 2014 in King County, Washington. Patient characteristics, manifestation of TB, and treatment outcomes in different age groups were compared. Frequency and type of adverse events that resulted in treatment interruption were evaluated and patients aged ≥65 years were compared with selected younger patients. RESULTS There were 403 patients who met the study criteria, 111 of whom were aged ≥65 years. Older patients were significantly less likely to have cavitation on chest radiographs. Patients aged ≥65 years were less likely to complete TB treatment (76.6% vs 94.9%, P < .0001) and were more likely to die during treatment (18.9% vs 2.1%, P < .0001). The difference in these outcomes was heightened for those aged ≥75 years compared with those aged |
| تدمد: | 1537-6591 1058-4838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33fe701f6b79955f86c22e570c4623f https://doi.org/10.1093/cid/ciz306 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a33fe701f6b79955f86c22e570c4623f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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