Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects
| العنوان: | Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects |
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| المؤلفون: | Tilman Hensch, Roland Mergl, Steffi G. Riedel-Heller, Christian Sander, Janek Spada, Dirk Alexander Wittekind, Jue Huang, Christine Ulke, Ulrich Hegerl, Tobias Luck, Philippe Jawinski, Nicole Mauche |
| المصدر: | The World Journal of Biological Psychiatry. 18:633-640 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Sleep Wake Disorders, medicine.medical_specialty, Anxiety, Audiology, Autonomic Nervous System, Non-rapid eye movement sleep, Arousal, 03 medical and health sciences, 0302 clinical medicine, Sleep debt, medicine, Insomnia, Humans, Biological Psychiatry, Aged, Slow-wave sleep, Sleep disorder, Depression, Anhedonia, Electroencephalography, medicine.disease, Up-Regulation, 030227 psychiatry, Psychiatry and Mental health, Female, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Although patients with depression often suffer from sleep disturbances, most of them are not sleepy. Upregulation of brain arousal has been proposed as pathophysiological mechanism explaining sleep disturbances, inner tension, autonomic hyperarousal and anhedonia in depression. The aim of the current study was to examine the association between night-time sleep disturbances and brain arousal regulation the next day in depressed versus non-depressed subjects.Twenty-eight elderly subjects (21 female; age = 70.5 ± 4.4 years) with depressive syndromes without psychotropic medication, and 28 controls (22 female; age = 70.9 ± 4.5 years), underwent a 15-min resting electroencephalogram; the Vigilance Algorithm Leipzig (VIGALL 2.1) provided an objective measure of brain arousal regulation. Sleep disturbances were assessed by a validated and self-rated sleep questionnaire.In the depressive group, but not in controls, more sleep disturbances were associated with a higher brain arousal stability score (high score corresponds to upregulation) the next day (sleep onset latency: rThe data confirm the hypothesis that in persons with depressive syndromes sleep disturbances are related to upregulation of brain arousal the next day. This finding is in line with the concept that dysregulation of brain arousal is a central pathophysiological aspect in depression. |
| تدمد: | 1814-1412 1562-2975 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34306712931a96494e9a38e2194b9d1 https://doi.org/10.1080/15622975.2016.1224924 |
| رقم الأكسشن: | edsair.doi.dedup.....a34306712931a96494e9a38e2194b9d1 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 18141412 15622975 |
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