Emerging roles of epigenetic regulation in obesity and metabolic disease
| العنوان: | Emerging roles of epigenetic regulation in obesity and metabolic disease |
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| المؤلفون: | Jin Young Huh, Sang Mun Han, Jae Bum Kim, Yoon Jeong Park |
| المصدر: | The Journal of Biological Chemistry |
| بيانات النشر: | American Society for Biochemistry and Molecular Biology, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | obesity, three-dimensional chromosome conformation, pCHi-C, promoter-capture Hi-C, TF, transcription factor, Adipose tissue, White adipose tissue, Biology, TET, ten-eleven translocation, Biochemistry, DNA methyltransferase, Chromatin remodeling, chromatin remodeling, Epigenesis, Genetic, Chromosome conformation capture, LAD, lamin-associated domain, Metabolic Diseases, SAM, S-adenosylmethione, TAD, topologically associated domain, Chromosomes, Human, Humans, Epigenetics, LSD1, lysine-specific demethylase-1, Molecular Biology, Epigenomics, 3C, chromosome conformation capture, DNA methylation, epigenetics, JBC Reviews, WAT, white adipose tissue, Cell Biology, CCCTC-binding factor, Cell biology, adipose tissue, DNMT, DNA methyltransferase, FATP1, fatty acid transporter protein 1, NAD, nucleolus-associated chromatin domain |
| الوصف: | Adipose tissue dysfunction is a hallmark of obesity and contributes to obesity-related sequelae such as metabolic complications and insulin resistance. Compelling evidence indicates that adipose-tissue-specific gene expression is influenced by gene interactions with proximal and distal cis-regulatory elements; the latter exert regulatory effects via three-dimensional (3D) chromosome conformation. Recent advances in determining the regulatory mechanisms reveal that compromised epigenomes are molecularly interlinked to altered cis-regulatory element activity and chromosome architecture in the adipose tissue. This review summarizes the roles of epigenomic components, particularly DNA methylation, in transcriptional rewiring in adipose tissue. In addition, we discuss the emerging roles of DNA methylation in the maintenance of 3D chromosome conformation and its pathophysiological significance concerning adipose tissue function. |
| اللغة: | English |
| تدمد: | 1083-351X 0021-9258 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a354fdbe9790ca2862f5b66a6bd75279 http://europepmc.org/articles/PMC8561000 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a354fdbe9790ca2862f5b66a6bd75279 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1083351X 00219258 |
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