Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma
| العنوان: | Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma |
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| المؤلفون: | Edikan A. Ogunnaike, Hongwei Du, Frances S. Ligler, Shawn Hingtgen, Barbara Savoldo, Alain Valdivia, Seema Nandi, Simon Khagi, Ernesto Leon, Gianpietro Dotti, Zhen Gu, Hannah Hudson, Mostafa Yazdimamaghani |
| المصدر: | Science Advances |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Multidisciplinary, biology, Chemistry, Immunology, SciAdv r-articles, medicine.disease, Fibrin, Chimeric antigen receptor, Therapeutic approach, biology.protein, Cancer research, medicine, Biomedicine and Life Sciences, Research Article, Cancer, Glioblastoma |
| الوصف: | Description In situ fibrin gel promotes the survival and the biodistribution of CAR-T cells, eliminating residual GBM cells after surgery. Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity. |
| تدمد: | 2375-2548 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36d90196dd5632951c9f272a0661263 https://doi.org/10.1126/sciadv.abg5841 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a36d90196dd5632951c9f272a0661263 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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