The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact
| العنوان: | The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact |
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| المؤلفون: | Percy Schröttner, Meike Burger, Marion Leick |
| المصدر: | Annals of Hematology. 89:437-446 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Leukocyte migration, medicine.medical_specialty, Chemokine, B-Lymphocyte Subsets, Lymphocyte Activation, Cell Movement, hemic and lymphatic diseases, Internal medicine, medicine, Animals, Humans, Hematology, biology, business.industry, General Medicine, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Haematopoiesis, Leukemia, medicine.anatomical_structure, Immunology, biology.protein, Receptors, Chemokine, Bone marrow, Chemokines, business, Homing (hematopoietic) |
| الوصف: | Chemokines are centrally involved in leukocyte migration, homing and haematopoiesis. Besides these physiological aspects, their role in pathological processes especially with respect to solid tumour and haematological neoplasias is well established. In this context, the focus was set here on disclosing their contribution in B cell chronic lymphocytic leukaemia (B-CLL), which is regarded as the most characteristic low-grade lymphoma. Up to now, it has been demonstrated that several chemokines are involved in migration of B-CLL cells to lymph nodes, secondary lymphoid organs and bone marrow. Moreover, some chemokines are known to have an anti-apoptotic effect and thus contribute to the survival of B-CLL cells. By interfering with both of these aspects, new therapeutic targets for this yet incurable disease may be developed. Furthermore, a correlation can be drawn between the concentration of some chemokines in patients' serum, the expression of their respective receptors on B-CLL cells and well-established predictive clinical parameters. Consequently, further systematic investigation of the chemokine network may lead to the identification of new diagnostic and prognostic markers. This review focuses on the impact of chemokines and their receptors on B-CLL pathophysiology and points out potential implications for both treatment and diagnosis. |
| تدمد: | 1432-0584 0939-5555 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37022f41733837a2907c264484605e7 https://doi.org/10.1007/s00277-009-0876-6 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a37022f41733837a2907c264484605e7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320584 09395555 |
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