Role of Interictal Arterial Spin Labeling Magnetic Resonance Perfusion in Mesial Temporal Lobe Epilepsy
| العنوان: | Role of Interictal Arterial Spin Labeling Magnetic Resonance Perfusion in Mesial Temporal Lobe Epilepsy |
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| المؤلفون: | Ashima Mittal, Gagandeep Singh, Devinder Pal Singh Dhanota, Archana Ahluwalia, Kavita Saggar |
| المصدر: | Annals of Indian Academy of Neurology Annals of Indian Academy of Neurology, Vol 24, Iss 4, Pp 495-500 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.diagnostic_test, business.industry, magnetic resonance imaging perfusion, cerebral blood flow, Magnetic resonance imaging, Context (language use), mesial temporal lobe epilepsy, Electroencephalography, medicine.disease, Arterial spin labelling, interictal, nervous system diseases, Epilepsy, Cerebral blood flow, medicine, Ictal, Original Article, Neurology (clinical), Neurology. Diseases of the nervous system, Cerebral perfusion pressure, business, Nuclear medicine, RC346-429, Perfusion |
| الوصف: | Context: Electrophysiological and hemodynamic data can be integrated to accurately identify the generators of abnormal electrical activity in drug-resistant focal epilepsy. Arterial Spin Labeling (ASL), a magnetic resonance imaging (MRI) technique for quantitative noninvasive measurement of cerebral blood flow (CBF), can provide a direct measure of variations in cerebral perfusion associated with the epileptogenic zone. Aims: 1. To evaluate usefulness of ASL for detecting interictal temporal hypoperfusion to localize the epileptogenic zone in patients of drug resistant mesial temporal lobe epilepsy (MTLE). 2. Correlation of localization of epileptogenic zone on ASL MR perfusion with structural MRI and EEG. Methods and Materials: 30 patients with MTLE and10 age and gender matched normal controls were studied. All patients underwent ictal video EEG monitoring non-invasively, MR imaging with epilepsy protocol and pseudocontinuous ASL (PCASL) perfusion study. Relative CBF (rCBF) values in bilateral mesial temporal lobes were measured utilizing quantitative analysis of perfusion images. A perfusion asymmetry index (AI) was calculated for each region. Results: In patients, ipsilateral mesial temporal rCBF was significantly decreased compared with contralateral mesial temporal rCBF (p = 0.021). Mesial temporal blood flow was more asymmetric in patients than in normal control participants (p = 0.000). Clear perfusion asymmetry on PCASL-MRI was identified despite normal structural-MRI in 5 cases, agreeing with EEG laterality. Conclusions: Pseudo-continuous ASL offers a promising approach to detect interictal hypoperfusion in TLE and as a clinical alternative to SPECT and PET due to non-invasiveness and easy accessibility. Incorporation of ASL into routine pre-surgical evaluation protocols can help to localize epileptogenic zone in surgical candidates. |
| تدمد: | 0972-2327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a381bae2b7c50d40ab226cdf19f66153 https://pubmed.ncbi.nlm.nih.gov/34728940 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a381bae2b7c50d40ab226cdf19f66153 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09722327 |
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