The capacity of APOB-depleted plasma in inducing ATP-binding cassette A1/G1-mediated macrophage cholesterol efflux-but not gut microbial-derived metabolites-is independently associated with mortality in patients with ST-segment elevation myocardial infarction
| العنوان: | The capacity of APOB-depleted plasma in inducing ATP-binding cassette A1/G1-mediated macrophage cholesterol efflux-but not gut microbial-derived metabolites-is independently associated with mortality in patients with ST-segment elevation myocardial infarction |
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| المؤلفون: | Canyelles, Marina, García Osuna, Álvaro, Junza, Alexandra, Yanes, O., Puig, N., Ordóñez-Llanos, J., Sionis, Alessandro, Sans-Roselló, J., Alquézar-Arbé, A, Santos, David, Rotllan, Noemi, Julve i Gil, Josep, Tondo, Mireia, Escola-Gil, Joan Carles, Blanco Vaca, Francisco, Universitat Autònoma de Barcelona |
| المصدر: | Biomedicines, Vol 9, Iss 1336, p 1336 (2021) Biomedicines Volume 9 Issue 10 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Apolipoprotein B, QH301-705.5, Trimethyllysine, Medicine (miscellaneous), Trimethylamine N-oxide, General Biochemistry, Genetics and Molecular Biology, Article, chemistry.chemical_compound, Internal medicine, medicine, Myocardial infarction, cardiovascular diseases, Biology (General), HDL-mediated efflux, biology, trimethylamine N-oxide, Unstable angina, business.industry, Cholesterol, Macrophages, medicine.disease, macrophages, Endocrinology, trimethyllysine, myocardial infarction, chemistry, ABCG1, ABCA1, biology.protein, lipids (amino acids, peptides, and proteins), Efflux, business |
| الوصف: | Altres ajuts: Fundació per a la Bioquímica Clínica i Patologia Molecular Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with cardiovascular death, but their interactions with HDL-mediated cholesterol efflux remain unclear. We aimed to determine the associations between APOB depleted plasma-mediated macrophage cholesterol efflux and plasma TMAO, γBB, and TML concentrations and explore their association with two-year follow-up mortality in patients with acute ST-elevation myocardial infarction (STEMI) and unstable angina (UA). Baseline and ATP-binding cassette transporter ABCA1 and ABCG1 (ABCA1/G1)-mediated macrophage cholesterol efflux to APOB-depleted plasma was decreased in patients with STEMI, and the latter was further impaired in those who died during follow-up. Moreover, the circulating concentrations of TMAO, γBB, and TML were higher in the deceased STEMI patients when compared with the STEMI survivors or UA patients. However, after statistical adjustment, only ABCA1/G1-mediated macrophage cholesterol efflux remained significantly associated with mortality. Furthermore, neither the TMAO, γBB, nor TML levels altered the HDL-mediated macrophage cholesterol efflux in vitro. We conclude that impaired ABCA1/G1-mediated macrophage cholesterol efflux is independently associated with mortality at follow-up in STEMI patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aa97cc40a3d50cd9872d5b9d81ac29 https://ddd.uab.cat/record/269616 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a3aa97cc40a3d50cd9872d5b9d81ac29 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |