Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats
| العنوان: | Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats |
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| المؤلفون: | Abdulhamit Battal, Fatih Donmez, Ozgur Ozan Anuk, Ali Aslan, Abdulahad Doğan |
| المصدر: | Volume: 10, Issue: 2 778-787 Journal of the Institute of Science and Technology |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Aché, Spleen, 02 engineering and technology, Pharmacology, 01 natural sciences, chemistry.chemical_compound, medicine, Biology, Butyrylcholinesterase, Ethanol, biology, 010405 organic chemistry, Chemistry, Neurotoxicity, 021001 nanoscience & nanotechnology, medicine.disease, Acetylcholinesterase, language.human_language, 0104 chemical sciences, medicine.anatomical_structure, Platanus orientalis,acetylcholinesterase,butyrylcholinesterase,adenosine deaminase,myeloperoxidase,ethanol, Myeloperoxidase, Toxicity, language, biology.protein, 0210 nano-technology, Biyoloji |
| الوصف: | In this study, immunotoxic and neurotoxic effects of leaf infusion of Platanus orientalis L. (PO) were investigated in rats ethanol-induced toxicity. Neurotoxic effects of ethanol were evaluated by measuring acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in rat brain tissue. Immunotoxic effects were evaluated by adenosine deaminase (ADA) and myeloperoxidase (MPO) biomarkers in rat liver, lung, erythrocyte and spleen tissues. Thirty male Wistar rats were divided into five groups after toxicity study. The groups are explained as follow: Control, Ethanol 20 %, Ethanol 20 % + Silymarin (10 mg kg-1), Ethanol 20 % + PO-20 mg mL-1 infusion and Ethanol 20 % + PO-60 mg mL-1 infusion. The results showed that AChE and BChE activities statistically decreased in the groups treated with PO leaf infusion. While there was a statistically significant decrease in ADA and MPO activities in liver tissue of groups treated with PO leaf infusion. Also, MPO activity of erythrocyte in ethanol group was significantlly increased according to silymarin and PO-60 groups. On the other hand, there was no statistically significant finding was found in lung and spleen tissues. It was concluded that the infusion prepared from P. orientalis leaves suppressed to ethanol-induced neurotoxicity and immunotoxicity. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2146-0574 2536-4618 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dd5adbb1f199235c0355dc6d852960 https://avesis.yyu.edu.tr/publication/details/06692caf-8b0a-4736-aba0-0d5884a86765/oai |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a3dd5adbb1f199235c0355dc6d852960 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21460574 25364618 |
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