Exploration and analysis of R-loop mapping data with RLBase
| العنوان: | Exploration and analysis of R-loop mapping data with RLBase |
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| المؤلفون: | Henry E Miller, Daniel Montemayor, Janet Li, Simon A Levy, Roshan Pawar, Stella Hartono, Kumar Sharma, Bess Frost, Frédéric Chedin, Alexander J R Bishop |
| المصدر: | Nucleic Acids Research. 51:D1129-D1137 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Genetics |
| الوصف: | R-loops are three-stranded nucleic acid structures formed from the hybridization of RNA and DNA. In 2012, Ginno et al. introduced the first R-loop mapping method. Since that time, dozens of R-loop mapping studies have been conducted, yielding hundreds of publicly available datasets. Current R-loop databases provide only limited access to these data. Moreover, no web tools for analyzing user-supplied R-loop datasets have yet been described. In our recent work, we reprocessed 810 R-loop mapping samples, building the largest R-loop data resource to date. We also defined R-loop consensus regions and developed a framework for R-loop data analysis. Now, we introduce RLBase, a user-friendly database that provides the capability to (i) explore hundreds of public R-loop mapping datasets, (ii) explore R-loop consensus regions, (iii) analyze user-supplied data and (iv) download standardized and reprocessed datasets. RLBase is directly accessible via the following URL: https://gccri.bishop-lab.uthscsa.edu/shiny/rlbase/. |
| تدمد: | 1362-4962 0305-1048 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f986c93b5de4feeb1581e76c5daaaf https://doi.org/10.1093/nar/gkac732 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a3f986c93b5de4feeb1581e76c5daaaf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 03051048 |
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