Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior
| العنوان: | Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior |
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| المؤلفون: | Efrat Hagai, Srinivasa Rao Ravella, Tim Harig, Veeramuthu Dharanishanthi, Amit Orgad, Julius Ben-Ari, Stefan Schulz, Jeny Kerstnus-Banchik, Yael Helman, Neta Rotem |
| المصدر: | Proc Natl Acad Sci U S A |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell physiology, Xanthomonas, Multidisciplinary, biology, Chemistry, Catabolite repression, Swarming (honey bee), food and beverages, Swarming motility, Biological Sciences, Hydrogen-Ion Concentration, Bacterial Physiological Phenomena, biology.organism_classification, Cell biology, Paenibacillus, biology.protein, Microbial Interactions, Signal transduction, Proteus mirabilis, Psychological repression, Flagellin |
| الوصف: | Bacteria have evolved a diverse array of signaling pathways that enable them to quickly respond to environmental changes. Understanding how these pathways reflect environmental conditions and produce an orchestrated response is an ongoing challenge. Herein, we present a role for collective modifications of environmental pH carried out by microbial colonies living on a surface. We show that by collectively adjusting the local pH value, Paenibacillus spp., specifically, regulate their swarming motility. Moreover, we show that such pH-dependent regulation can converge with the carbon repression pathway to down-regulate flagellin expression and inhibit swarming in the presence of glucose. Interestingly, our results demonstrate that the observed glucose-dependent swarming repression is not mediated by the glucose molecule per se, as commonly thought to occur in carbon repression pathways, but rather is governed by a decrease in pH due to glucose metabolism. In fact, modification of the environmental pH by neighboring bacterial species could override this glucose-dependent repression and induce swarming of Paenibacillus spp. away from a glucose-rich area. Our results suggest that bacteria can use local pH modulations to reflect nutrient availability and link individual bacterial physiology to macroscale collective behavior. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3faec8f1615fbcb0cf9ebb2dac575b9 https://doi.org/10.1073/pnas.2014346118 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a3faec8f1615fbcb0cf9ebb2dac575b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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