Lack of Interaction between a Polymorphism in the Dopamine D2 Receptor Gene and the Clinical Features of Migraine
| العنوان: | Lack of Interaction between a Polymorphism in the Dopamine D2 Receptor Gene and the Clinical Features of Migraine |
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| المؤلفون: | C Mazza, E Pavanelli, N Rebaudengo, F Rosina, A Parziale, Luca Ostacoli, Pier Maria Furlan, Innocenzo Rainero, Elisa Rubino |
| المصدر: | Cephalalgia. 24:503-507 |
| بيانات النشر: | SAGE Publications, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Aura, Migraine Disorders, Disease, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Internal medicine, Dopamine receptor D2, Genotype, Humans, Medicine, 030212 general & internal medicine, Allele frequency, Analysis of Variance, Chi-Square Distribution, Polymorphism, Genetic, Receptors, Dopamine D2, business.industry, General Medicine, Middle Aged, medicine.disease, Migraine with aura, Migraine, Anesthesia, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | The purpose of this study was to evaluate whether a particular genotype of the dopamine D2 receptor (DRD2) gene would affect the clinical features of migraine. In a group of 118 migraineurs (55 migraine with aura and 63 migraine without aura patients), we tested the association of the biallelic C/T NcoI DRD2 polymorphism with several characteristics of the disease. Genotype and allele frequencies resulted similarly distributed in migraine with aura and migraine without aura patients (χ2 = 1.58, P = 0.45 and χ2 = 0.09, P = 0.77, respectively). The different DRD2 genotypes (C/C, C/T and T/T) had no significant effects on age at onset of migraine, presence of premonitory phenomena, frequency of headache attacks, associated symptoms, psychological features and quality of life of our migraine patients. The results of our study do not support a role for the DRD2 gene in modifying the clinical features of migraine. |
| تدمد: | 1468-2982 0333-1024 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fcaf961298a2ea27bece2ad1b1b1af https://doi.org/10.1111/j.1468-2982.2004.00689.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a3fcaf961298a2ea27bece2ad1b1b1af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682982 03331024 |
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