In vivo integrity of polymer-coated gold nanoparticles
| العنوان: | In vivo integrity of polymer-coated gold nanoparticles |
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| المؤلفون: | Alexander Wenk, Idoia Ruiz de Larramendi, Abuelmagd M. Abdelmonem, Teofilo Rojo, Joanna Rejman, Gülnaz Khadem-Saba, Marianne Geiser, Roser Ufartes, Dorleta Jimenez de Aberasturi, Jose-Maria Montenegro, Nadine Haberl, Frauke Alves, Karsten Kantner, Wolfgang J. Parak, Stephanie Hirn, Wolfgang G. Kreyling, Raimo Hartmann, Zulqurnain Ali |
| المصدر: | Nature Nanotechnology. 10:619-623 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Materials science, Polymers, Biomedical Engineering, Metal Nanoparticles, Nanoparticle, Bioengineering, Nanotechnology, Rats, Inbred WKY, Coated Materials, Biocompatible, In vivo, Animals, Tissue Distribution, General Materials Science, Particle Size, Electrical and Electronic Engineering, chemistry.chemical_classification, Polymer, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Rats, Colloidal nanoparticles, Viscera, chemistry, Organ Specificity, Colloidal gold, Drug delivery, Female, Gold, sense organs |
| الوصف: | Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their physicochemical properties, and it is well known that their colloidal properties may change upon internalization by cells. While the stability of such nanoparticles is typically assayed in simple in vitro tests, their stability in a mammalian organism remains unknown. Here, we show that firmly grafted polymer shells around gold nanoparticles may degrade when injected into rats. We synthesized monodisperse radioactively labelled gold nanoparticles ((198)Au) and engineered an (111)In-labelled polymer shell around them. Upon intravenous injection into rats, quantitative biodistribution analyses performed independently for (198)Au and (111)In showed partial removal of the polymer shell in vivo. While (198)Au accumulates mostly in the liver, part of the (111)In shows a non-particulate biodistribution similar to intravenous injection of chelated (111)In. Further in vitro studies suggest that degradation of the polymer shell is caused by proteolytic enzymes in the liver. Our results show that even nanoparticles with high colloidal stability can change their physicochemical properties in vivo. |
| تدمد: | 1748-3395 1748-3387 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b58558c51609131c7265834d8b0353 https://doi.org/10.1038/nnano.2015.111 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a4b58558c51609131c7265834d8b0353 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17483395 17483387 |
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