Initiating TrkB/Akt Signaling Cascade Preserves Blood–Brain Barrier after Subarachnoid Hemorrhage in Rats
| العنوان: | Initiating TrkB/Akt Signaling Cascade Preserves Blood–Brain Barrier after Subarachnoid Hemorrhage in Rats |
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| المؤلفون: | Juan Liu, Jianfei Lu, Jiejin Wu, Junjia Tang, Guiyun Zhang, Cong Han, Yunke Bi, Meiqing Lou, Xiangqian Qi |
| المصدر: | Cell Transplantation Cell Transplantation, Vol 28 (2019) |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Subarachnoid hemorrhage, Indoles, subarachnoid hemorrhage, tight junction, Perforation (oil well), Biomedical Engineering, lcsh:Medicine, tropomyosin-related kinase receptor b, Brain Edema, Tropomyosin receptor kinase B, Pharmacology, Blood–brain barrier, blood–brain barrier, Rats, Sprague-Dawley, early brain injury, Piperidines, medicine, Animals, Receptor, trkB, cardiovascular diseases, Receptor, PI3K/AKT/mTOR pathway, Transplantation, Glycogen Synthase Kinase 3 beta, Tight junction, business.industry, lcsh:R, Water, Cell Biology, Original Articles, medicine.disease, nervous system diseases, medicine.anatomical_structure, nervous system, Blood-Brain Barrier, Serotonin, business, Proto-Oncogene Proteins c-akt, Signal Transduction |
| الوصف: | The integrity of the blood–brain barrier (BBB) plays a vital role in affecting the prognosis of subarachnoid hemorrhage (SAH). This study aimed to investigate activation of the Tropomyosin-related kinase receptor B (TrkB) and its downstream signaling pathway on preserving BBB breakdown after experimental SAH. An endovascular perforation SAH model was applied. N-[2-(5-hydroxy-1H-indol-3-yl) ethyl]-2- oxopiperidine-3-carboxamide (HIOC), the derivative of N-acetyl serotonin (NAS), was intracerebroventricularly administered 3 h after SAH induction. The neurologic scores and brain water content were evaluated in an outcome study. Western blot and immunofluorescence staining were used to investigate the mechanism. The results indicated that HIOC activated the TrkB/Akt pathway, increased the tight junction expression, improved neurologic deficits, and ameliorated brain edema after SAH. Thus, we conclude that initiating the TrkB/Akt signaling cascade preserves BBB breakdown after experimental SAH in rats. |
| اللغة: | English |
| تدمد: | 1555-3892 0963-6897 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b5c3efe9c644e055931986e554bb8b http://europepmc.org/articles/PMC6728706 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a4b5c3efe9c644e055931986e554bb8b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15553892 09636897 |
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