Purple tulip extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied
| العنوان: | Purple tulip extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied |
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| المؤلفون: | Frank Himbert, Mayoura Keophiphath, Léana Manzato, Elise Huguet, Sylvie Boisnic, Anne‐Sophie Dussert, Amélie Herlin, Philippe Bernard, Jean-Christophe Choulot, Marie-Christine Branchet, Neila Hajem, Shalina Hassanaly |
| المصدر: | Journal of Cosmetic Dermatology. 20:691-702 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Volunteers, Tulipa, Human skin, Dermatology, Pharmacology, Biology, Skin Aging, Extracellular matrix, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Collagen VI, Gene expression, Collagen network, Humans, Cells, Cultured, Aged, Skin, integumentary system, Plant Extracts, Genomics, Fibroblasts, Fibronectin, 030220 oncology & carcinogenesis, biology.protein, Female, Ex vivo |
| الوصف: | Background Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products. Objectives We aimed to evaluate the effects of purple tulip extract on skin quality and to determine its molecular modes of interaction. Methods A pangenomic study on human skin fibroblasts was carried out to analyse multiple changes in gene expression. Ex vivo studies of human skin explants exposed to ultraviolet (UV) irradiation or H2 O2 were performed to assess modulations of protein expression. Finally, a clinical assay was carried out to evaluate the efficacy of purple tulip extract on skin appearance and condition of aged women. Results Genetic modulation analyses led us to infer the induction of many biological functions including cell differentiation, proliferation, migration, inflammatory responses, and matrix remodelling. The ex vivo studies revealed an enhancement of the collagen network and increased expression of glycosaminoglycans (GAG), fibronectin and collagen VI. Finally, the clinical study highlighted the potential anti-ageing properties of the purple tulip extract which decreased the relaxation of the oval face and improved skin elasticity after 28 days of treatment. Significant reductions of the length and depth of the nasolabial wrinkles were also observed. Conclusion Our genomics data on the effect of purple tulip extract on the ex vivo UV challenged skin, showed that genes responsible for, amongst others, the upkeep of the skin, such as collagen induction, immune cell proliferation and epidermal repair, were all upregulated. More importantly, the clinical study corroborated these data by the visible and measurable effects of the topical purple tulip extract on the aged skin of 22 women, further demonstrating the beneficial impact of the extract on aged skin. |
| تدمد: | 1473-2165 1473-2130 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d21d9f89fa13dd7bded708324d6099 https://doi.org/10.1111/jocd.13583 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a4d21d9f89fa13dd7bded708324d6099 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732165 14732130 |
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