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Prognostic value of gross tumor regression and plasma Epstein Barr Virus DNA levels at the end of intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma

التفاصيل البيبلوغرافية
العنوان: Prognostic value of gross tumor regression and plasma Epstein Barr Virus DNA levels at the end of intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma
المؤلفون: Hai Zhao, Shao Bo Liang, Dan Ming Chen, Yong Chen, Bin Hong Chen, Li-Wu Fu, Ning Zhang, Xing Li Yang, Rui Liang Lu
المصدر: Radiotherapy and Oncology. 132:223-229
بيانات النشر: Elsevier BV, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, Oncology, Epstein-Barr Virus Infections, Herpesvirus 4, Human, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Virus, 030218 nuclear medicine & medical imaging, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, otorhinolaryngologic diseases, Tumor regression, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Aged, 80 and over, Nasopharyngeal Carcinoma, medicine.diagnostic_test, business.industry, Epstein-Barr virus DNA, Nasopharyngeal Neoplasms, Magnetic resonance imaging, Hematology, Middle Aged, Prognosis, medicine.disease, Primary tumor, Survival Rate, Radiation therapy, stomatognathic diseases, Nasopharyngeal carcinoma, Lymphatic Metastasis, 030220 oncology & carcinogenesis, DNA, Viral, Multivariate Analysis, Female, Lymph Nodes, Radiotherapy, Intensity-Modulated, Lymph, Neoplasm Recurrence, Local, business
الوصف: To assess gross tumor regression and plasma Epstein-Barr virus (EBV)-DNA levels at the end of intensity-modulated radiation therapy (IMRT) and its prognostic impact on patients with nasopharyngeal carcinoma (NPC).In total, 397 patients with non-metastatic, histologically confirmed NPC were retrospectively examined. All patients underwent magnetic resonance imaging of the nasopharynx and neck, and plasma EBV DNA assays before treatment and at the end of IMRT.The estimated 5-year loco-regional, local and regional relapse-free survival rates for patients with complete response (CR) and non-CR of the total tumor, primary tumor and metastatic lymph nodes at the end of IMRT were 94.9% vs. 85.8%, 96.6% vs. 87.3%, and 98.7% vs. 89.8%, respectively (P 0.05). The estimated 5-year loco-regional relapse-free survival (LRRFS) rates for patients with persistent tumor with and without boost irradiation were 95.3% vs. 83%, respectively (P = 0.034). The estimated 5-year overall survival (OS), failure-free survival (FFS) and distant metastasis-free survival (DMFS) rates for patients with negative and positive plasma EBV DNA at the end of IMRT were 83.1% vs. 50.3%, 81.5% vs. 49.3%, and 87.6% vs. 61.5%, respectively (P 0.001). Multivariate analyses indicated that regression of the total tumor and boost irradiation was an independent predictor of LRRFS, and plasma EBV DNA levels were independent predictors of OS, FFS and DMFS.Gross tumor regression and plasma EBV DNA levels at the end of IMRT served as predictors of poor prognosis for patients with NPC. The patients with persistent tumor and/or positive plasma EBV DNA might require timely strengthening treatment.
تدمد: 0167-8140
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5268c53c6deb60c59cdd87452107386
https://doi.org/10.1016/j.radonc.2018.10.010
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....a5268c53c6deb60c59cdd87452107386
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01678140