Astragaloside IV Promotes Adult Neurogenesis in Hippocampal Dentate Gyrus of Mouse through CXCL1/CXCR2 Signaling
| العنوان: | Astragaloside IV Promotes Adult Neurogenesis in Hippocampal Dentate Gyrus of Mouse through CXCL1/CXCR2 Signaling |
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| المؤلفون: | Zhibi Hu, Hui Wu, Xiaojun Wu, Fei Huang, Liyue Qin, Yunyi Lan, Qinrui Zou, Huaihuai Dong, Hailian Shi |
| المصدر: | Molecules Volume 23 Issue 9 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules, Vol 23, Iss 9, p 2178 (2018) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Chemokine CXCL1, Pharmaceutical Science, Hippocampus, Hippocampal formation, Receptors, Interleukin-8B, Analytical Chemistry, Mice, 0302 clinical medicine, Drug Discovery, CXCL1/CXCR2, CXC chemokine receptors, Cells, Cultured, biology, Neurogenesis, Neural stem cell, Up-Regulation, CXCL1, neurogenesis, Chemistry (miscellaneous), Molecular Medicine, Signal Transduction, medicine.medical_specialty, Doublecortin Protein, Article, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Internal medicine, mental disorders, medicine, Animals, Physical and Theoretical Chemistry, proliferative radial gila-like cells, Cell Proliferation, Dentate gyrus, Organic Chemistry, astragaloside IV, newly generated neurons, Saponins, early proliferative cells, Triterpenes, 030104 developmental biology, Endocrinology, nervous system, Dentate Gyrus, biology.protein, NeuN, 030217 neurology & neurosurgery |
| الوصف: | Astragaloside IV (ASI) has been reported to promote neural stem cells proliferation in vitro and CXCR2 expression on neutrophils. The present study was aimed to investigate the influence of ASI on adult neurogenesis in hippocampal dentate gyrus (DGs) of mouse and to discuss the possible underlying mechanisms. Total number of proliferative cells (BrdU+), pre-mature neurons (DCX+), early proliferative cells (BrdU+/DCX+), proliferative radial gila-like cells (BrdU+/GFAP+) and newly generated neurons (BrdU+/NeuN+) after ASI or vehicle administration for two weeks were counted, respectively. The results showed that BrdU+ cells and DCX+ cells were significantly increased in DGs of mice administered with ASI. The numbers of BrdU+/DCX+, BrdU+/GFAP+ cells and BrdU+/NeuN+ cells were also elevated in the ASI group. Correspondingly, ASI increased the protein expression of hippocampal DCX, GFAP and NeuN. Further study disclosed that ASI remarkably up-regulated the mRNA and protein expressions of CXCL1 as well as that of CXCR2 in the hippocampus. The promotive effect of ASI on DCX, GFAP and NeuN protein expression was abolished by SB225002, the inhibitor of CXCR2. Our results indicated that ASI modulated the homeostasis of the CXCL1/CXCR2 signaling pathway, which might be responsible for the increased neurogenesis within the hippocampal DGs of mice. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| DOI: | 10.3390/molecules23092178 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6039c183da969f910ae01af8f2795bc |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a6039c183da969f910ae01af8f2795bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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| DOI: | 10.3390/molecules23092178 |