Genes influencing milk production traits predominantly affect one of four biological pathways
| العنوان: | Genes influencing milk production traits predominantly affect one of four biological pathways |
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| المؤلفون: | Michael E. Goddard, Amanda J. Chamberlain, H McPartlan |
| المساهمون: | Revues Inra, Import |
| المصدر: | Genetics, Selection, Evolution : GSE Genetics Selection Evolution Genetics Selection Evolution, BioMed Central, 2008, 40 (1), pp.79-89 Genetics Selection Evolution, Vol 40, Iss 1, Pp 79-89 (2008) |
| بيانات النشر: | Springer Nature |
| مصطلحات موضوعية: | independent traits, Genetic Linkage, Efficiency, 02 engineering and technology, chemistry.chemical_compound, bivariate analysis, Pleiotropy, Lactation, Genetics(clinical), Lactose, ComputingMilieux_MISCELLANEOUS, lcsh:SF1-1100, Genetics, 2. Zero hunger, 0303 health sciences, 04 agricultural and veterinary sciences, General Medicine, Dairying, Milk, medicine.anatomical_structure, Trait, Female, Signal Transduction, lcsh:QH426-470, Quantitative Trait Loci, 0206 medical engineering, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, genome scan, Quantitative trait locus, Biology, Biological pathway, 03 medical and health sciences, Animal science, pleiotropy, mental disorders, medicine, Animals, Dairy cattle, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Models, Genetic, Research, 0402 animal and dairy science, Quantitative genetics, 040201 dairy & animal science, lcsh:Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, chemistry, Animal Science and Zoology, lcsh:Animal culture, false discovery rate, 020602 bioinformatics |
| الوصف: | In this study we introduce a method that accounts for false positive and false negative results in attempting to estimate the true proportion of quantitative trait loci that affect two different traits. This method was applied to data from a genome scan that was used to detect QTL for three independent milk production traits, Australian Selection Index (ASI), protein percentage (P%) and fat percentage corrected for protein percentage (F% – P%). These four different scenarios are attributed to four biological pathways: QTL that (1) increase or decrease total mammary gland production (affecting ASI only); (2) increase or decrease lactose synthesis resulting in the volume of milk being changed but without a change in protein or fat yield (affecting P% only); (3) increase or decrease protein synthesis while milk volume remains relatively constant (affecting ASI and P% in the same direction); (4) increase or decrease fat synthesis while the volume of milk remains relatively constant (affecting F% – P% only). The results indicate that of the positions that detected a gene, most affected one trait and not the others, though a small proportion (2.8%) affected ASI and P% in the same direction. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1297-9686 0999-193X |
| DOI: | 10.1186/1297-9686-40-1-79 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a607c3c8fde6886eb7330f762df14c0e |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a607c3c8fde6886eb7330f762df14c0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12979686 0999193X |
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| DOI: | 10.1186/1297-9686-40-1-79 |