Implications of renin‐angiotensin‐system blocker discontinuation in acute decompensated heart failure with systolic dysfunction
| العنوان: | Implications of renin‐angiotensin‐system blocker discontinuation in acute decompensated heart failure with systolic dysfunction |
|---|---|
| المؤلفون: | Wilfried Mullens, W.H. Wilson Tang, Mark H. Drazner, Douglas Darden, Justin L. Grodin, Matthias Dupont |
| المصدر: | Clinical Cardiology |
| بيانات النشر: | Wiley Periodicals, Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, renal failure, acute decompensated heart failure, Acute decompensated heart failure, Clinical Investigations, Renal function, Angiotensin-Converting Enzyme Inhibitors, 030204 cardiovascular system & hematology, Ventricular Function, Left, Renin-Angiotensin System, 03 medical and health sciences, chemistry.chemical_compound, Angiotensin Receptor Antagonists, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Blood urea nitrogen, Aged, Retrospective Studies, Creatinine, Heart Failure, Diastolic, business.industry, Stroke Volume, General Medicine, Middle Aged, medicine.disease, ARB, Discontinuation, Blood pressure, Treatment Outcome, chemistry, Withholding Treatment, Heart failure, Cohort, Acute Disease, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, ACEI, RASB, Follow-Up Studies |
| الوصف: | Background Renin‐angiotensin‐system blockers (RASB) improve clinical outcomes in patients with chronic heart failure with reduced fraction; however, there remains ambiguity whether RASB therapy should be continued during the treatment of acute decompensated heart failure (ADHF). Hypothesis In comparison to patients with RASB use, RASB discontinuation in ADHF will be associated with worsening renal function, hypotension, and adverse long‐term clinical outcomes. Methods Patients in the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization (ESCAPE) trial were separated into four groups based on RASB use at baseline and discharge: continuation (n = 316), discontinuation (n = 21), initiation (n = 42), and nonuse (n = 23). Post‐discharge outcomes were validated in an independent ADHF cohort admitted to the Cleveland Clinic (n = 253). Results RASB discontinuation and nonuse were associated with higher serial creatinine and blood urea nitrogen levels than RASB continuation or initiation (P |
| اللغة: | English |
| تدمد: | 1932-8737 0160-9289 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6103756de7dd090f389e400596a379a http://europepmc.org/articles/PMC6788475 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a6103756de7dd090f389e400596a379a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19328737 01609289 |
|---|