Simulation in a production process represents the realization of processes in time and space. In manufacturing, the current trend is towards the implementation and expansion of various types of systems in many industrial enterprises. This effort is supported by requirements to increase reliability, eliminate production times and costs, as well as meet operational schedules. The presented article is focused on the possibilities of alternative approaches to the rationalization of production processes using simulation methods. The introduction of this article is devoted to the issue of simulations in general with a brief overview of historical development and classification of simulation tools. The second part of the article describes the tools used for comparative rationalization, which forms the core of the presented article. The conclusion summarizes the findings of the study.