Anti-Inflammatory Mechanisms of the Tibetan Herbal Preparation Padma 28 in the Vessel Wall
| العنوان: | Anti-Inflammatory Mechanisms of the Tibetan Herbal Preparation Padma 28 in the Vessel Wall |
|---|---|
| المؤلفون: | Oswald Wagner, Markus Exner, Bernhard Gmeiner, Marianne Raith, Stylianos Kapiotis, Gregor Holzer |
| المصدر: | Forschende Komplementärmedizin / Research in Complementary Medicine. 13:13-17 |
| بيانات النشر: | S. Karger AG, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Arteriosclerosis, medicine.drug_class, Treatment outcome, Anti-Inflammatory Agents, Anti-inflammatory, law.invention, Peripheral arterial occlusive disease, law, medicine, Humans, Medicine, Tibetan Traditional, Cells, Cultured, biology, Traditional medicine, Plant Extracts, business.industry, C-reactive protein, medicine.disease, C-Reactive Protein, Treatment Outcome, Complementary and alternative medicine, biology.protein, Blood Vessels, E-Selectin, Phytotherapy, business, Heme Oxygenase-1 |
| الوصف: | The Tibetan herbal preparation Padma 28 has been shown to act as an anti-atherosclerotic agent in advanced peripheral arterial occlusive disease. We tested the effect of aqueous Padma 28 extracts on both the Creactive protein (CRP) induced expression of the pro-inflammatory cell adhesion molecule E-selectin and the anti-atherosclerotic protective enzyme heme oxygenase- 1 (HO-1) in human aortic endothelial cells.According to FACS analysis, quantitative RT-PCR and Western blot, CRP-induced E-selectin expression was completely prevented by aqueous Padma 28 extracts. Additionally, Padma 28 mediated an up to 60-fold upregulation of HO-1 mRNA as measured by quantitative RT-PCR. This upregulation could also be demonstrated on the protein level.Aqueous extracts of the Tibetan herbal preparation Padma 28 inhibit CRP-induced expression of the inflammatory cell adhesion molecule E-selectin and lead to upregulation of the vascular protective enzyme HO-1 in human aortic endothelial cells. These properties may be responsible for its anti-atherosclerotic effects in peripheral arterial occlusive disease. |
| تدمد: | 1661-4127 1661-4119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c7524e4216f4978cd8f83ca1b7cb1a https://doi.org/10.1159/000090435 |
| رقم الأكسشن: | edsair.doi.dedup.....a6c7524e4216f4978cd8f83ca1b7cb1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16614127 16614119 |
|---|