Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease: a meta-analysis study (N=7277)
| العنوان: | Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease: a meta-analysis study (N=7277) |
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| المؤلفون: | Niamh X. Cawley, Loh Yp, Liu Tt, Cao C, Yong Cheng, Xiao-Yan Qin, Yuan J |
| المصدر: | Molecular Psychiatry. 22:312-320 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, Neurotrophic factors, Statistical significance, Internal medicine, medicine, Humans, Dementia, Cognitive Dysfunction, Psychiatry, Molecular Biology, Aged, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor, medicine.disease, Confidence interval, Psychiatry and Mental health, 030104 developmental biology, Schizophrenia, Meta-analysis, Disease Progression, Female, Psychopharmacology, Psychology, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Studies suggest that dysfunction of brain-derived neurotrophic factor (BDNF) is a possible contributor to the pathology and symptoms of Alzheimer's disease (AD). Several studies report reduced peripheral blood levels of BDNF in AD, but findings are inconsistent. This study sought to quantitatively summarize the clinical BDNF data in patients with AD and mild cognitive impairment (MCI, a prodromal stage of AD) with a meta-analytical technique. A systematic search of Pubmed, PsycINFO and the Cochrane Library identified 29 articles for inclusion in the meta-analysis. Random-effects meta-analysis showed that patients with AD had significantly decreased baseline peripheral blood levels of BDNF compared with healthy control (HC) subjects (24 studies, Hedges' g=-0.339, 95% confidence interval (CI)=-0.572 to -0.106, P=0.004). MCI subjects showed a trend for decreased BDNF levels compared with HC subjects (14 studies, Hedges' g=-0.201, 95% CI=-0.413 to 0.010, P=0.062). No differences were found between AD and MCI subjects in BDNF levels (11 studies, Hedges' g=0.058, 95% CI=-0.120 to 0.236, P=0.522). Interestingly, the effective sizes and statistical significance improved after excluding studies with reported medication in patients (between AD and HC: 18 studies, Hedges' g=-0.492, P |
| تدمد: | 1476-5578 1359-4184 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76d5a4c53b27036bae4dae98e5e7288 https://doi.org/10.1038/mp.2016.62 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a76d5a4c53b27036bae4dae98e5e7288 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765578 13594184 |
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