From bench to bedside: GP IIb-IIIa inhibitors
| العنوان: | From bench to bedside: GP IIb-IIIa inhibitors |
|---|---|
| المؤلفون: | Dan J. Fintel |
| المصدر: | Neurology. 57:S12-S19 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, business.industry, Platelet Glycoprotein GPIIb-IIIa Complex, medicine.disease, Bioinformatics, Thrombosis, Bench to bedside, Blockade, Stroke, Pathogenesis, Mechanism of action, Antithrombotic, medicine, Humans, Platelet, Neurology (clinical), Intracranial Thrombosis, medicine.symptom, Receptor, business, Platelet Aggregation Inhibitors |
| الوصف: | Our understanding of the pathophysiology of acute coronary syndromes (ACS) has now been substantiated by many studies showing that atherothrombosis plays a predominant role. This article reviews the molecular interactions in thrombosis that may serve as therapeutic targets for more effective management of these syndromes. In particular, the discovery of the fact that the glycoprotein (GP) IIb-IIIa receptor plays a central and common role in platelet-mediated thrombosis has focused the therapeutic efforts. Blockade of this receptor has emerged as a new and potent strategy for inhibition of platelet aggregation and thus of clot formation. A number of trials have now corroborated the need for such antithrombotic drugs in the management of patients with non-ST-segment elevation ACS. |
| تدمد: | 1526-632X 0028-3878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a787a4feb361716105e9e3b021af017f https://doi.org/10.1212/wnl.57.suppl_2.s12 |
| رقم الأكسشن: | edsair.doi.dedup.....a787a4feb361716105e9e3b021af017f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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