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Effects of a combined dietary, exercise and behavioral intervention and sympathetic system on body weight maintenance after intended weight loss: Results of a randomized controlled trial

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العنوان: Effects of a combined dietary, exercise and behavioral intervention and sympathetic system on body weight maintenance after intended weight loss: Results of a randomized controlled trial
المؤلفون: Reiner Jumpertz von Schwartzenberg, Thomas Bobbert, Maria Brachs, Verena Leupelt, Heiko Krude, Annette Grüters-Kieslich, Joachim Spranger, Andrea Ernert, Knut Mai, Lukas Maurer
المصدر: Metabolism. 83:60-67
بيانات النشر: Elsevier BV, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Sympathetic Nervous System, Diet, Reducing, Endocrinology, Diabetes and Metabolism, Psychological intervention, 030204 cardiovascular system & hematology, Energy homeostasis, Body Weight Maintenance, law.invention, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Randomized controlled trial, Weight regain, Behavior Therapy, law, Weight loss, Internal medicine, Intervention (counseling), Weight Loss, medicine, Humans, Obesity, 030212 general & internal medicine, Life Style, business.industry, Middle Aged, medicine.disease, Combined Modality Therapy, Exercise Therapy, Weight Reduction Programs, Treatment Outcome, Female, medicine.symptom, business
الوصف: Background Lifestyle based weight loss interventions are hampered by long-term inefficacy. Prediction of individuals successfully reducing body weight would be highly desirable. Although sympathetic activity is known to contribute to energy homeostasis, its predictive role in body weight maintenance has not yet been addressed. Objectives We investigated, whether weight regain could be modified by a weight maintenance intervention and analyzed the predictive role of weight loss-induced changes of the sympathetic system on long-term weight regain. Design 156 subjects (age > 18; BMI ≥ 27 kg/m2) participated in a 12-week weight reduction program. After weight loss (T0), 143 subjects (weight loss > 8%) were randomized to a 12-month lifestyle intervention or a control group. After 12 months (T12) no further intervention was performed until month 18 (T18). Weight regain at T18 (regainBMI) was the primary outcome. Evaluation of systemic and tissue specific estimates of sympathetic system was a pre-defined secondary outcome. Results BMI was reduced by 4.67 ± 1.47 kg/m2 during the initial weight loss period. BMI maintained low in subjects of the intervention group until T12 (+0.07 ± 2.98 kg/m2; p = 0.58 compared to T0), while control subjects regained +0.98 ± 1.93 kg/m2 (p Conclusions Our lifestyle intervention successfully maintained body weight during the intervention period. However, no long-term effect could be observed beyond the intervention period. Predictive sympathetic activity was not persistently modified by the intervention, which may partially explain the lack of long-term success of such interventions.
تدمد: 0026-0495
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b0f7f20f82d02ca1a5888f7c11156b
https://doi.org/10.1016/j.metabol.2018.01.003
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....a7b0f7f20f82d02ca1a5888f7c11156b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00260495