Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
| العنوان: | Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers |
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| المؤلفون: | Cheryl Frye, Peter A. Steck, Michelle Baumgard, Bradley D. Swedlund, Samar A. Jasser, W. K. A. Yung, Rong Hu, Mark A. Pershouse, Azra H. Ligon, David H. F. Teng, Huai Lin, Lauren A. Langford, Sean V. Tavtigian, Thaylon Davis, T. Hattier |
| المصدر: | Nature Genetics. 15:356-362 |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, Tumor suppressor gene, DNA Mutational Analysis, Molecular Sequence Data, Auxilin, Biology, medicine.disease_cause, Mice, Gene mapping, Neoplasms, Tumor Cells, Cultured, Genetics, medicine, Animals, Humans, Tensin, Genes, Tumor Suppressor, Amino Acid Sequence, RNA, Messenger, RNA, Neoplasm, Gene, Cells, Cultured, Regulation of gene expression, Sequence Homology, Amino Acid, Chromosomes, Human, Pair 10, Tumor Suppressor Proteins, PTEN Phosphohydrolase, Chromosome, Phosphoric Monoester Hydrolases, Gene Expression Regulation, Neoplastic, Mutation, Cancer research, Protein Tyrosine Phosphatases, Glioblastoma, Carcinogenesis |
| الوصف: | Deletions involving regions of chromosome 10 occur in the vast majority (> 90%) of human glioblastoma multiformes. A region at chromosome 10q23-24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers. |
| تدمد: | 1546-1718 1061-4036 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d0f8a1525861e9b5288ca1c1a8c324 https://doi.org/10.1038/ng0497-356 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a7d0f8a1525861e9b5288ca1c1a8c324 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461718 10614036 |
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