Correction to: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
| العنوان: | Correction to: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery |
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| المؤلفون: | Suresh Poudel, Junmin Peng, Kaushik Kumar Dey, Hong Wang, Ping-Chung Chen, Bing Bai, Ka Yang, David Vanderwall, Yuxin Li, Xusheng Wang |
| المصدر: | Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-1 (2021) Molecular Neurodegeneration |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Proteomics, medicine.medical_specialty, Neurology, Proteome, MEDLINE, Datasets as Topic, Nerve Tissue Proteins, Plaque, Amyloid, Computational biology, Disease, Pathogenesis, Cellular and Molecular Neuroscience, Meta-Analysis as Topic, Alzheimer Disease, Tandem Mass Spectrometry, Data Mining, Humans, Medicine, Cognitive Dysfunction, Biomarker discovery, Databases, Protein, RC346-429, Molecular Biology, business.industry, RC952-954.6, Correction, Cerebrospinal Fluid Proteins, Blood Proteins, Molecular medicine, Geriatrics, Asymptomatic Diseases, Neurology. Diseases of the nervous system, Neurology (clinical), business, Protein Processing, Post-Translational, Biomarkers, Chromatography, Liquid |
| الوصف: | Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the advances and limitations in historic and recent AD proteomic research. Complementary to genetic mapping, proteomic studies not only validate canonical amyloid and tau pathways, but also uncover novel components in broad protein networks, such as RNA splicing, development, immunity, membrane transport, lipid metabolism, synaptic function, and mitochondrial activity. Meta-analysis of seven deep datasets reveals 2,698 differentially expressed (DE) proteins in the landscape of AD brain proteome (n = 12,017 proteins/genes), covering 35 reported AD genes and risk loci. The DE proteins contain cellular markers enriched in neurons, microglia, astrocytes, oligodendrocytes, and epithelial cells, supporting the involvement of diverse cell types in AD pathology. We discuss the hypothesized protective or detrimental roles of selected DE proteins, emphasizing top proteins in "amyloidome" (all biomolecules in amyloid plaques) and disease progression. Comprehensive PTM analysis represents another layer of molecular events in AD. In particular, tau PTMs are correlated with disease stages and indicate the heterogeneity of individual AD patients. Moreover, the unprecedented proteomic coverage of biofluids, such as cerebrospinal fluid and serum, procures novel putative AD biomarkers through meta-analysis. Thus, proteomics-driven systems biology presents a new frontier to link genotype, proteotype, and phenotype, accelerating the development of improved AD models and treatment strategies. |
| تدمد: | 1750-1326 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f9e746e5220db2a1a0331e3976dc05 https://doi.org/10.1186/s13024-021-00493-w |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a7f9e746e5220db2a1a0331e3976dc05 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17501326 |
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