التفاصيل البيبلوغرافية
العنوان:
The discovery and structure–activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase
المؤلفون:
Eugene C. Amparo , Srinivas K. Chunduru , Ariamala Gopalsamy , Christopher A. Benetatos , Lori E. Miller , Tandy L. Draper , Christopher J. Burns , Matthew G. LaPorte , Lara K. Leister , Torsten Herbertz , Dorothy C. Young , Stephen M. Condon , Blackledge Charles W , Gerry Rhodes , Alison R. Hussey
المصدر:
Bioorganic & Medicinal Chemistry Letters . 20:2968-2973
بيانات النشر:
Elsevier BV, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
Indoles , Stereochemistry , Hepatitis C virus , Clinical Biochemistry , Allosteric regulation , Pharmaceutical Science , Viral Nonstructural Proteins , Crystallography, X-Ray , medicine.disease_cause , Antiviral Agents , Biochemistry , Virus , Structure-Activity Relationship , Drug Discovery , medicine , Structure–activity relationship , Enzyme Inhibitors , Binding site , Molecular Biology , Pyrans , chemistry.chemical_classification , Indole test , Binding Sites , biology , Organic Chemistry , virus diseases , digestive system diseases , Enzyme , chemistry , Enzyme inhibitor , biology.protein , Molecular Medicine
الوصف:
We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82b0bf920d396980908e52cb23485ed https://doi.org/10.1016/j.bmcl.2010.03.002
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....a82b0bf920d396980908e52cb23485ed
قاعدة البيانات:
OpenAIRE
