The Use of Molecular Probes to Distinguish New Primary Tumors from Recurrent Tumors in Gynecologic Malignancies
| العنوان: | The Use of Molecular Probes to Distinguish New Primary Tumors from Recurrent Tumors in Gynecologic Malignancies |
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| المؤلفون: | Shu-Yuan Liao, Alberto Manetta, Jeffrey D. Bloss, Sharon P. Wilczynski, M L Berman, Joan L. Walker |
| المصدر: | American Journal of Clinical Pathology. 94:432-434 |
| بيانات النشر: | Oxford University Press (OUP), 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Adult, Pathology, medicine.medical_specialty, Uterine Cervical Neoplasms, Biology, Malignancy, Neoplasms, Multiple Primary, chemistry.chemical_compound, Biopsy, medicine, Humans, DNA Probes, HPV, Cervix, Cervical cancer, medicine.diagnostic_test, Nucleic Acid Hybridization, DNA Restriction Enzymes, DNA, Neoplasm, General Medicine, medicine.disease, Restriction enzyme, medicine.anatomical_structure, chemistry, Carcinoma, Squamous Cell, Vagina, Female, Neoplasm Recurrence, Local, Molecular probe, DNA |
| الوصف: | This is the first report using DNA molecular probe technology to distinguish between recurrent tumor and a second primary malignancy in a patient. Tumor DNA was extracted from squamous cell carcinoma of the cervix at the time of radical hysterectomy. Eighteen months later a squamous cell cancer was found in a vaginal apex biopsy from which DNA was extracted. Tumor DNA from both lesions was subjected to restriction enzyme digestion and DNA molecular hybridization with human papillomavirus (HPV) probes. Although both lesions were positive for HPV 16, their respective restriction enzyme patterns had different HPV genetic arrangements, thereby demonstrating their distinctness. |
| تدمد: | 1943-7722 0002-9173 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b56bbc335582ce5872d9ce130b911b https://doi.org/10.1093/ajcp/94.4.432 |
| رقم الأكسشن: | edsair.doi.dedup.....a8b56bbc335582ce5872d9ce130b911b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19437722 00029173 |
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