Unexpected postmortem diagnoses in cases of clinically diagnosed amyotrophic lateral sclerosis

التفاصيل البيبلوغرافية
العنوان: Unexpected postmortem diagnoses in cases of clinically diagnosed amyotrophic lateral sclerosis
المؤلفون: Gen Sobue, Takashi Kameyama, Mikiko Kamijo, Keizo Yasui, Yuichi Riku, Masahisa Katsuno, Mari Yoshida, Yasushi Iwasaki, Takuya Tamura
المصدر: Neuropathology : official journal of the Japanese Society of NeuropathologyREFERENCES. 41(6)
سنة النشر: 2021
مصطلحات موضوعية: Motor Neurons, Pathology, medicine.medical_specialty, Movement disorders, business.industry, Amyloidosis, Amyotrophic Lateral Sclerosis, Dysautonomia, Autopsy, General Medicine, Disease, Motor neuron, medicine.disease, Pathology and Forensic Medicine, medicine.anatomical_structure, medicine, Disease Progression, Humans, Neurology (clinical), Amyotrophic lateral sclerosis, medicine.symptom, Motor Neuron Disease, business, Pathological
الوصف: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that is clinically and pathologically characterized by impairment of the upper and lower motor neurons. The clinical diagnosis of ALS is not always straightforward because of the lack of specific biomarkers and clinical heterogeneity. This review presents the clinical and pathological findings of four autopsied cases that had been diagnosed with ALS before death. These cases had demonstrated definite and progressive motor neuron signs and symptoms, whereas postmortem assessment revealed miscellaneous disorders, including fungal infection, paraneoplastic syndrome, and amyloidosis. Importantly, nonmotor neuron signs and symptoms, including seizures, extra-pyramidal signs, ocular movement disorders, sensory disturbance, and dysautonomia, had also been documented during the disease course of the cases in the present study. The ALS-unlike symptoms were indicative of the "true" diagnosis in each case when those symptoms were isolated from motor neuron signs/symptoms.
تدمد: 1440-1789
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94eabb30c86ddd27c84a7e3c2c358c4
https://pubmed.ncbi.nlm.nih.gov/34783101
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....a94eabb30c86ddd27c84a7e3c2c358c4
قاعدة البيانات: OpenAIRE