Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche
العنوان: | Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche |
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المؤلفون: | Yuyang Gan, Hailin Wang, Lijuan Du, Kaitao Li, Qian Qu, Weiwen Liu, Pingping Sun, Zhexiang Fan, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao |
المصدر: | Stem Cell Reviews and Reports. 18:2016-2027 |
بيانات النشر: | Springer Science and Business Media LLC, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | Cell Differentiation, Epithelial Cells, Mesenchymal Stem Cells, Hair Follicle, Cells, Cultured |
الوصف: | Mesenchymal stem cells (MSCs) are known for their self-renewal and multi-lineage differentiation potential, with these cells often being evaluated in the regulation and maintenance of specific cellular niches including those of the hair follicle. Most mesenchymal stem cells in the hair follicles are housed in the dermal papilla (DP) and dermal sheath (DS), with both niches characterized by a broad variety of cellular subsets. However, while most previous studies describing the hair follicle mesenchymal niche treated all DP and DS cells as Hair Follicle Mesenchymal Stem Cells (HF-MSCs), the high number of cellular subsets would suggest that these cells are actually too heterogenous for such a broad definition. Given this we designed this study to evaluate the differentiation processes in these cells and used this data to create a new set of classifications for DP and DS cells, dividing them into "hair follicle mesenchymal stem cells (HF-MSCs)", "hair follicle mesenchymal progenitor cells (HF-MPCs)", and "hair follicle mesenchymal functional cells (HF-MFCs)". In addition, those cells that possess self-renewal and differentiation were re-named hair follicle derived mesenchymal multipotent cells (HF-MMCs). This new classification may help to further our understanding of the heterogeneity of hair follicle dermal cells and provide new insights into their evaluation. |
تدمد: | 2629-3277 2629-3269 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9570cbcfee78a955c862ce9b6d8bdcd https://doi.org/10.1007/s12015-022-10411-2 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....a9570cbcfee78a955c862ce9b6d8bdcd |
قاعدة البيانات: | OpenAIRE |
تدمد: | 26293277 26293269 |
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