التفاصيل البيبلوغرافية
| العنوان: |
Data from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness |
| المؤلفون: |
Olivier Soriani, Franck Borgese, Patrick Martin, Maria Luisa Cayuela, Sophie Tartare-Deckert, Marco Presta, Agnès Paquet, Alexandra Popa, Agnès Loubat, Bernard Pellissier, Hélène Guizouarn, Sonia Martial, Giuseppina Gariano, Mélanie Tichet, Francisca Alcaraz-Perez, Raphael Rapetti-Mauss, David Crottès |
| بيانات النشر: |
American Association for Cancer Research (AACR), 2023. |
| سنة النشر: |
2023 |
| الوصف: |
The sigma 1 receptor (Sig1R) is a stress-activated chaperone that regulates ion channels and is associated with pathologic conditions, such as stroke, neurodegenerative diseases, and addiction. Aberrant expression levels of ion channels and Sig1R have been detected in tumors and cancer cells, such as myeloid leukemia and colorectal cancer, but the link between ion channel regulation and Sig1R overexpression during malignancy has not been established. In this study, we found that Sig1R dynamically controls the membrane expression of the human voltage-dependent K+ channel human ether-à-go-go-related gene (hERG) in myeloid leukemia and colorectal cancer cell lines. Sig1R promoted the formation of hERG/β1-integrin signaling complexes upon extracellular matrix stimulation, triggering the activation of the PI3K/AKT pathway. Consequently, the presence of Sig1R in cancer cells increased motility and VEGF secretion. In vivo, Sig1R expression enhanced the aggressiveness of tumor cells by potentiating invasion and angiogenesis, leading to poor survival. Collectively, our findings highlight a novel function for Sig1R in mediating cross-talk between cancer cells and their microenvironment, thus driving oncogenesis by shaping cellular electrical activity in response to extracellular signals. Given the involvement of ion channels in promoting several hallmarks of cancer, our study also offers a potential strategy to therapeutically target ion channel function through Sig1R inhibition. Cancer Res; 76(3); 607–18. ©2015 AACR. |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9786af395eb339cd81b89a31b87c89f
https://doi.org/10.1158/0008-5472.c.6507779 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....a9786af395eb339cd81b89a31b87c89f |
| قاعدة البيانات: |
OpenAIRE |
