Hyperglycemia-stimulating diet induces liver steatosis in sheep
| العنوان: | Hyperglycemia-stimulating diet induces liver steatosis in sheep |
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| المؤلفون: | Hay Dvir, Ramgopal Mopuri, Uzi Moallem, Mugagga Kalyesubula, Nir Edery, Alexander Rosov, Tamir Alon |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Lipolysis, medicine.medical_treatment, Science, Interleukin-1beta, Adipose tissue, Fatty Acids, Nonesterified, Severity of Illness Index, Article, 03 medical and health sciences, Insulin resistance, Non-alcoholic Fatty Liver Disease, Internal medicine, Leukocytes, medicine, Animals, Obesity, Chemokine CCL2, Triglycerides, Sheep, Multidisciplinary, Tumor Necrosis Factor-alpha, business.industry, Insulin, Metabolic disorder, Fatty liver, 0402 animal and dairy science, Metabolic diseases, 04 agricultural and veterinary sciences, medicine.disease, Metabolic syndrome, 040201 dairy & animal science, Diet, 030104 developmental biology, Endocrinology, Adipose Tissue, Liver, Hyperglycemia, Lipogenesis, Medicine, Steatosis, Fat metabolism, business |
| الوصف: | Hepatic steatosis is strongly associated with chronic liver disease and systemic metabolic disorder. Adipose lipolysis is a recognized principal source of intrahepatic fat in various metabolic disorders, including non-alcoholic fatty liver disease. We hypothesized that, in the premorbid state, hepatic de novo lipogenesis (DNL) driven by excess carbohydrates abundance might play a more significant role. We employed a novel nutritional model in sheep of two distinct carbohydrates abundances. During 4 months of the dietary treatment, lambs were monitored for metabolic and terminal liver parameters. Lambs grown on the high-calorie (HC) diet were consistently more hyperglycemic and hyperinsulinemic than lambs grown on the lower-calorie (LC) diet (P P P P P CCL2 (P TNF-alpha (P IL1B trended higher (P P P |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a995c58f1d67e3c5b1ef1a539c6545dc https://doaj.org/article/50c5163424224121a15cac57f3cef2f1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a995c58f1d67e3c5b1ef1a539c6545dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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