Adrenocorticotropic hormone and β-endorphin concentration as a prognostic factor in patients with subarachnoid hemorrhage due to aneurysmal rupture
| العنوان: | Adrenocorticotropic hormone and β-endorphin concentration as a prognostic factor in patients with subarachnoid hemorrhage due to aneurysmal rupture |
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| المؤلفون: | Ha-Young Choi, Hyoung-Gyu Jang, Geo-seong Park, Jung-Soo Park, Jong-Myeong Lee, Eun-Jeong Koh |
| المصدر: | Journal of Cerebrovascular and Endovascular Neurosurgery. 24:113-120 |
| بيانات النشر: | Korean Society of Cerebrovascular Surgeons/Korean Society of Endovascular Surgery, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | endocrine system, medicine.medical_specialty, Prognostic factor, Subarachnoid hemorrhage, Stroke scale, business.industry, Neurological status, Adrenocorticotropic hormone, medicine.disease, Gastroenterology, nervous system diseases, Internal medicine, medicine, In patient, cardiovascular diseases, Acute stress, business, hormones, hormone substitutes, and hormone antagonists, Blood sampling |
| الوصف: | Objective: Adrenocorticotropic hormone (ACTH) and β-endorphin are pituitary neuro-peptides released by acute stress. We determined why the prognosis of patients with subarachnoid hemorrhages (SAH) due to aneurysmal rupture is not always dependent on the Hunt–Hess grading system (HHS) and delta-National Institutes of Health Stroke Scale (NIHSS), while studying endogenous neuropeptides, including ACTH and β-endorphin.Methods: We analyzed blood samples collected from patients with SAH (SAH group; n=37) and those with unruptured intracranial aneurysms (control group; n=37). Blood sampling was performed before any procedure or chemical agents administration. The results of ACTH and β-endorphin measurements were compared using the delta-NIHSS and HHS. The data were analyzed using descriptive statistics, independent samples t-tests, and Pearson’s correlations.Results: Of the 18 patients with low-grade HHS, 13 had low delta-NIHSS and five showed high delta-NIHSS. Of the 19 patients with high-grade HHS, the delta-NIHSS was ≥14 in the other five patients. ACTH concentration was high (497.3 pg/mL) in five patients with high-grade HHS and high delta-NIHSS. β-endorphin concentration was high (159.7 pg/mL) in 13 patients with low-grade HHS and low delta-NIHSS.Conclusions: High ACTH levels in patients with massive bleeding and poor neurological status suggests increasing ACTH secretion in response to bleeding stress, which may aggravate neurological status. Contrary to ACTH, high β-endorphin levels in patients with low-grade HHS implied the involvement of additional factors in predicting fair outcomes related to low delta-NIHSS. These results may provide insight into the varying prognostic potential of HHS in SAH patients. |
| تدمد: | 2287-3139 2234-8565 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99b45b870d5e734f8097f87936064a5 https://doi.org/10.7461/jcen.2021.e2021.08.003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a99b45b870d5e734f8097f87936064a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22873139 22348565 |
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