Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis
| العنوان: | Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis |
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| المؤلفون: | Nanne K. H. de Boer, Sofia el Manouni el Hassani, Marc A. Benninga, Jorrit Broertjes, Mirjam E. van de Velde, Tim G. J. de Meij, Gertjan L. Kaspers, Andries E. Budding |
| المساهمون: | Pediatric surgery, CCA - Cancer Treatment and quality of life, Gastroenterology and hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Paediatric Gastroenterology |
| المصدر: | Journal of Pediatric Hematology / Oncology, 44(1), E152-E159. Lippincott Williams and Wilkins Journal of pediatric hematology/oncology, 44(1), E152-E159. Lippincott Williams and Wilkins van de Velde, M E, el Manouni el Hassani, S, Kaspers, G J L, Broertjes, J, Benninga, M A, de Boer, N K H, Budding, A E & de Meij, T G J 2022, ' Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis ', Journal of Pediatric Hematology / Oncology, vol. 44, no. 1, pp. E152-E159 . https://doi.org/10.1097/MPH.0000000000002210 |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Microbial diversity, Pilot Projects, Gastroenterology, Electronic nose, Feces, fluids and secretions, Internal medicine, Bloodstream infection, Sepsis, medicine, Chemotherapy, Humans, Child, Diagnostics, Invasive infection, Pediatric leukemia, Acute leukemia, Volatile Organic Compounds, biology, Toxicity, business.industry, Microbiota, Neutropenic fever, Bacteroidetes, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, biology.organism_classification, bacterial infections and mycoses, Gastrointestinal Microbiome, Leukemia, Myeloid, Acute, Oncology, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, human activities, Microbiota composition |
| الوصف: | Introduction Bloodstream infections (BSIs) cause treatment-related mortality in pediatric acute leukemia. We explored the potential of intestinal microbiota and fecal volatile organic compounds (VOCs) analyses to predict BSI. Methods In this case-control study, fecal samples of pediatric acute leukemia patients were collected. Microbiota composition and fecal VOC profiles of BSI cases and matched non-BSI controls were compared. Results In total, 6 patients were included, of which 1 developed BSI and 1 neutropenic fever. Both showed reduced microbial diversity and stability of Bacteroidetes. In the BSI case, Pantoea was identified 15 days before BSI. Significant differences in fecal VOC profiles were measured between the case and controls. Conclusion Microbiota and fecal VOC could serve as biomarkers to predict BSI in pediatric leukemia. |
| اللغة: | English |
| تدمد: | 1077-4114 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a321b04be00b1ad2c158998d8f5c51 https://research.vumc.nl/en/publications/56eb9cad-d258-48cf-a9e5-308cf2b11e8a |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....a9a321b04be00b1ad2c158998d8f5c51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10774114 |
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