Synovial Fluid Mesenchymal Stem Cells for Knee Arthritis and Cartilage Defects: A Review of the Literature
| العنوان: | Synovial Fluid Mesenchymal Stem Cells for Knee Arthritis and Cartilage Defects: A Review of the Literature |
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| المؤلفون: | William Fang, ZhiTao Sun, Bo Han, Xiao Chen, C. Thomas Vangsness |
| المصدر: | The Journal of Knee Surgery. 34:1476-1485 |
| بيانات النشر: | Georg Thieme Verlag KG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | education.field_of_study, Pathology, medicine.medical_specialty, business.industry, Arthritis, Cartilage, Mesenchymal stem cell, Population, Cell Differentiation, Mesenchymal Stem Cells, Chondrogenesis, Regenerative medicine, medicine.anatomical_structure, Synovial Fluid, medicine, Animals, Humans, Synovial fluid, Orthopedics and Sports Medicine, Surgery, Bone marrow, business, education, Adult stem cell |
| الوصف: | Mesenchymal stem cells (MSCs) are adult stem cells that have the ability to self-renew and differentiate into several cell lineages including adipocytes, chondrocytes, tenocytes, bones, and myoblasts. These properties make the cell a promising candidate for regenerative medicine applications, especially when dealing with sports injuries in the knee. MSCs can be isolated from almost every type of adult tissue. However, most of the current research focuses on MSCs derived from bone marrow, adipose, and placenta derived products. Synovial fluid-derived MSCs (SF-MSCs) are relatively overlooked but have demonstrated promising therapeutic properties including possessing higher chondrogenic proliferation capabilities than other types of MSCs. Interestingly, SF-MSC population has shown to increase exponentially in patients with joint injury or disease, pointing to a potential use as a biomarker or as a treatment of some orthopaedic disorders. In this review, we go over the current literature on synovial fluid-derived MSCs including the characterization, the animal studies, and discuss future perspectives. |
| تدمد: | 1938-2480 1538-8506 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9af16299d5a7a6df77539c2eb85845b https://doi.org/10.1055/s-0040-1710366 |
| رقم الأكسشن: | edsair.doi.dedup.....a9af16299d5a7a6df77539c2eb85845b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19382480 15388506 |
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