Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio)
| العنوان: | Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio) |
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| المؤلفون: | B. Verschuere, J.-G. Passagia, N. Rajaofetra, L. Marlier, Alain Privat, Michel Geffard, F. Pellas, P. Poulat, F. Sandillon, D. Gouy |
| المصدر: | The Journal of Comparative Neurology. 318:1-17 |
| بيانات النشر: | Wiley, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Male, Serotonin, Calcitonin Gene-Related Peptide, Enkephalin, Methionine, Central nervous system, Urination, Neuropeptide, Substance P, Biology, Serotonergic, Norepinephrine, chemistry.chemical_compound, Cordotomy, medicine, Animals, Neurons, Afferent, Thyrotropin-Releasing Hormone, General Neuroscience, Neuropeptides, Anatomy, Spinal cord, Immunohistochemistry, Microscopy, Electron, medicine.anatomical_structure, Spinal Cord, chemistry, Onuf's nucleus, Nucleus, Neuroscience, Enkephalin, Leucine, Papio, medicine.drug |
| الوصف: | We have investigated with light and electron microscope immunocytochemistry the aminergic and peptidergic innervation of Onuf's nucleus in adult baboons. This nucleus, located in the ventrolateral part of the sacral spinal cord (S2 and S3), is considered to control urethral and anal sphincters and penile muscles. By comparison of intact and transected spinal cords, we have found that serotoninergic innervation has two origins: first, supraspinal, innervating the whole nucleus, with a possible predominance in the dorsal half; and second, intraspinal, corresponding to the ventral half of the nucleus. Thyrotropin-releasing hormone innervation appears largely coincident with serotonin, both in intact and transected spinal cords. Noradrenaline is exclusively of supraspinal origin, as attested by its disappearance below the level of the section. Substance P, calcitonin genex-related peptide, and Leux- and Metx-enkephalin, which profusely innervate Onuf's nucleus, are on the contrary not affected by the transection. They most likely originate from the cord itself or the dorsal root ganglia. Thus, Onuf's nucleus innervation in the baboon arises both from supraspinal and intraspinal sources. The present study provides an anatomical basis for both voluntary and reflex controls of excretory and sexual functions in a primate. The same neurotransmitter (serotonin) according to its cell origin and discrete topography could exert different influences upon the same effector system. |
| تدمد: | 1096-9861 0021-9967 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e8e3c76b28cd4a898f93f63de8097d https://doi.org/10.1002/cne.903180102 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....a9e8e3c76b28cd4a898f93f63de8097d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969861 00219967 |
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