Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer’s disease
| العنوان: | Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer’s disease |
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| المؤلفون: | Juliet M. Taylor, Zachery Moore, Myles R. Minter, Peter J Crack |
| المصدر: | Journal of Neural Transmission. 125:797-807 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Amyloid beta, Disease, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, medicine, Animals, Humans, Biological Psychiatry, Neuroinflammation, Inflammation, Microglia, biology, business.industry, Neurodegeneration, Brain, medicine.disease, Biochemistry of Alzheimer's disease, Psychiatry and Mental health, 030104 developmental biology, medicine.anatomical_structure, Neurology, Interferon Type I, Nerve Degeneration, Immunology, biology.protein, Cytokine secretion, Neurology (clinical), Alzheimer's disease, business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Past research in Alzheimer's disease (AD) has largely been driven by the amyloid hypothesis; the accompanying neuroinflammation seen in AD has been assumed to be consequential and not disease modifying or causative. However, recent data from both clinical and preclinical studies have established that the immune-driven neuroinflammation contributes to AD pathology. Key evidence for the involvement of neuroinflammation in AD includes enhanced microglial and astroglial activation in the brains of AD patients, increased pro-inflammatory cytokine burden in AD brains, and epidemiological evidence that chronic non-steroidal anti-inflammatory drug use prior to disease onset leads to a lower incidence of AD. Identifying critical mediators controlling this neuroinflammation will prove beneficial in developing anti-inflammatory therapies for the treatment of AD. The type-I interferons (IFNs) are pleiotropic cytokines that control pro-inflammatory cytokine secretion and are master regulators of the innate immune response that impact on disorders of the central nervous system. This review provides evidence that the type-I IFNs play a critical role in the exacerbation of neuroinflammation and actively contribute to the progression of AD. |
| تدمد: | 1435-1463 0300-9564 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fd31589285d7ca53678eb842536aa8 https://doi.org/10.1007/s00702-017-1745-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a9fd31589285d7ca53678eb842536aa8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14351463 03009564 |
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