Vitamin A Supplementation and Human Immunodeficiency Virus Type 1 Shedding in Women: Results of a Randomized Clinical Trial
| العنوان: | Vitamin A Supplementation and Human Immunodeficiency Virus Type 1 Shedding in Women: Results of a Randomized Clinical Trial |
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| المؤلفون: | Daniel D. Bankson, Julie Overbaugh, Joan K. Kreiss, Kishorchandra Mandaliya, Barbra A. Richardson, Jeckoniah O. Ndinya-Achola, Jared M. Baeten, R. Scott McClelland, Sandra Emery, Ludo Lavreys, Job J. Bwayo |
| المصدر: | The Journal of Infectious Diseases. 185:1187-1191 |
| بيانات النشر: | Oxford University Press (OUP), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Vitamin, medicine.medical_specialty, Adolescent, Physiology, Biology, Placebo, law.invention, chemistry.chemical_compound, Double-Blind Method, Randomized controlled trial, law, Retinyl palmitate, Internal medicine, medicine, Humans, Immunology and Allergy, Viral shedding, Vitamin A, Acquired Immunodeficiency Syndrome, Vitamin A Deficiency, Retinol, Middle Aged, medicine.disease, Virus Shedding, Vitamin A deficiency, Infectious Diseases, Endocrinology, medicine.anatomical_structure, chemistry, Dietary Supplements, Vagina, HIV-1, Female, Follow-Up Studies |
| الوصف: | Observational studies have associated vitamin A deficiency with vaginal shedding of human immunodeficiency virus (HIV) type 1-infected cells and mother-to-child HIV-1 transmission. To assess the effect of vitamin A supplementation on vaginal shedding of HIV-1, a randomized, double-blind, placebo-controlled trial of 6 weeks of daily oral vitamin A (10,000 IU of retinyl palmitate) was conducted among 400 HIV-1-infected women in Mombasa, Kenya. At follow-up, there was no statistically significant difference in the prevalence of HIV-1 DNA (18% vs. 21%, P=.4) or the quantity of HIV-1 RNA (3.12 vs. 3.00 log(10) copies/swab, P=1.0) in vaginal secretions of women receiving vitamin A, compared with women receiving placebo. No significant effect of supplementation on plasma HIV-1 load or CD4 or CD8 cell counts was observed, and no effect was seen among women who were vitamin A deficient at baseline. Vitamin A supplementation is unlikely to decrease the infectivity of women infected with HIV-1. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1136dd2869d293eb41f4ef44dfa0c8 https://doi.org/10.1086/339823 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aa1136dd2869d293eb41f4ef44dfa0c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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