Effect of Carrier Lipophilicity and Preparation Method on the Properties of Andrographolide–Solid Dispersion
| العنوان: | Effect of Carrier Lipophilicity and Preparation Method on the Properties of Andrographolide–Solid Dispersion |
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| المؤلفون: | Shoude Zhang, Qingyun Zeng, Guowei Zhao, Ya-Shao Chen, Liquan Ou, Zheng-Gen Liao, Youquan Zhong, Changhao Wang |
| المصدر: | Pharmaceutics Volume 11 Issue 2 Pharmaceutics, Vol 11, Iss 2, p 74 (2019) |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | lcsh:RS1-441, Pharmaceutical Science, 02 engineering and technology, Polyethylene glycol, carrier lipophilicity, 030226 pharmacology & pharmacy, Article, lcsh:Pharmacy and materia medica, 03 medical and health sciences, chemistry.chemical_compound, Crystallinity, 0302 clinical medicine, PEG ratio, Thermal stability, Dissolution, chemistry.chemical_classification, solid dispersion, Chemistry, andrographolide, technology, industry, and agriculture, Polymer, 021001 nanoscience & nanotechnology, Chemical engineering, Lipophilicity, preparation method, 0210 nano-technology, Dispersion (chemistry) |
| الوصف: | Solid dispersion (SD) is a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble drugs. This work investigated the effects of carrier material lipophilicity and preparation method on the properties of andrographolide (AG)&ndash SD. The SDs of AG and the carrier materials, polyethylene glycol (PEG) and PEG grafted with carbon chains of different length (grafted PEG), have been prepared by spray-drying and vacuum-drying methods. In AG&ndash SDs prepared by the different preparation methods with the same polymer as carrier material, the intermolecular interaction, 5% weight-loss temperature, the melting temperature (Tm), surface morphology, crystallinity, and dissolution behavior have significant differences. In the AG&ndash SDs prepared by the same spray-drying method with different grafted PEG as carrier material, Tm, surface morphology, crystallinity, and dissolution behavior had little difference. In the AG&ndash SDs prepared by the same vacuum-drying method with different grafted PEG as carrier material, the crystallinity and Tm decreased, and the dissolution rate of AG increased with the increase of grafted PEG lipophilicity. The preparation method has an important effect on the properties of SD. The increase of carrier material lipophilicity is beneficial to the thermal stability of SD, the decrease of crystallinity and the increase of dissolution rate of a poorly water-soluble drug in the SD. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4923 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4691b5160ee1445de9428c41d9137d http://europepmc.org/articles/PMC6409804 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aa4691b5160ee1445de9428c41d9137d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994923 |
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