A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids

التفاصيل البيبلوغرافية
العنوان: A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids
المؤلفون: Shigeru Yamada, Hiroyuki Masuno, Hiroyuki Kagechika, Aya Tanatani, Yasunari Kanda
المصدر: Biologicalpharmaceutical bulletin. 45(11)
سنة النشر: 2022
مصطلحات موضوعية: Pharmacology, Organoids, Induced Pluripotent Stem Cells, Pharmaceutical Science, Humans, Lithocholic Acid, Cell Differentiation, General Medicine, Intestinal Mucosa, Vitamin D
الوصف: Vitamin D is a fat-soluble micronutrient that plays essential roles in a range of biological processes, including cell proliferation, inflammation, and metabolism. In this study, we investigated the effects of a novel synthetic lithocholic acid derivative with vitamin D activity (Dcha-20) on pharmacokinetic gene expression in human induced pluripotent stem cell-derived intestinal organoids. Compared with vitamin D
تدمد: 1347-5215
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d74f03ec0215149382078b18107a8
https://pubmed.ncbi.nlm.nih.gov/36328508
رقم الأكسشن: edsair.doi.dedup.....aa5d74f03ec0215149382078b18107a8
قاعدة البيانات: OpenAIRE