SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study
| العنوان: | SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study |
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| المؤلفون: | Cecilia Zivelonghi, Alessandro Dinoto, Sarosh R. Irani, Andrew McKeon, Andrea Pilotto, Alessandro Padovani, Stefano Masciocchi, Eugenio Magni, Chiara R. Mancinelli, Ruggero Capra, Giorgia T. Maniscalco, Irene Volonghi, Ava Easton, Daniela Alberti, Gianluigi Zanusso, Salvatore Monaco, Gian Luca Salvagno, Giuseppe Lippi, Sergio Ferrari, Sara Mariotto |
| المصدر: | Immunologic Research. |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | SARS-CoV-2, Immunology, Encephalitis, Demyelinating disorders, Viral trigger |
| الوصف: | It is well established that neurological and non-neurological autoimmune disorders can be triggered by viral infections. It remains unclear whether SARS-CoV-2 infection induces similar conditions and whether they show a distinctive phenotype. We retrospectively identified patients with acute inflammatory CNS conditions referred to our laboratory for antibody testing during the pandemic (March 1 to August 31, 2020). We screened SARS-COV-2 IgA/IgG in all sera by ELISA and confirmed the positivity with additional assays. Clinical and paraclinical data of SARS-COV-2-IgG seropositive patients were compared to those of seronegative cases matched for clinical phenotype, geographical zone, and timeframe. SARS-CoV-2-IgG positivity was detected in 16/339 (4%) sera, with paired CSF positivity in 3/16. 5 of these patients had atypical demyelinating disorders and 11 autoimmune encephalitis syndromes. 9/16 patients had a previous history of SARS-CoV-2 infection and 6 of them were symptomatic. In comparison with 32 consecutive seronegative controls, SARS-CoV-2-IgG-positive patients were older, frequently presented with encephalopathy, had lower rates of CSF pleocytosis and other neurological autoantibodies, and were less likely to receive immunotherapy. When SARS-CoV-2 seropositive versus seronegative cases with demyelinating disorders were compared no differences were seen. Whereas seropositive encephalitis patients less commonly showed increased CSF cells and protein, our data suggest that an antecedent symptomatic or asymptomatic SARS-CoV-2 infection can be detected in patients with autoimmune neurological conditions. These cases are rare, usually do not have specific neuroglial antibodies. |
| تدمد: | 1559-0755 0257-277X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa99cecdb572be035536c312d2818a99 https://doi.org/10.1007/s12026-023-09384-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aa99cecdb572be035536c312d2818a99 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15590755 0257277X |
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