Effects of propofol on IGF-1 activity and cell behaviour in the GES 1 mucosal cell model
| العنوان: | Effects of propofol on IGF-1 activity and cell behaviour in the GES 1 mucosal cell model |
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| المؤلفون: | Chai, Hua, Peng, Wenyong, Zhu, Zhongquan, Xiong, Chang, Jin, Xiayun |
| المصدر: | Growth Factors. 41:32-42 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Endocrinology, Clinical Biochemistry, Cell Biology |
| الوصف: | Propofol is an important and widely used anaesthetic drug in the clinic. Many works have shown that propofol has important biological functions except as an anaesthetic. In the current study, we mainly explored the effect of propofol on the biological activity of IGF-1, which is an important growth factor involved in regulating the growth and development of the stomach. Here, we explored the effect of propofol on the biological activity of IGF-1 in a GES-1-cell model. We found that propofol affected the biological activity of IGF-1. It not only reduces IGF-1/IGF-1R signalling but also changes IGF-1R cell characteristics. We further explored the mechanism by which propofol affected IGF-1 activity. Through a series of experiments, we found that propofol affected the stability of membrane-localised IGF-1R. It also affects the recycling of the IGF-1R receptor Propofol can affect the degradation of IGF-1R by changing the endocytosis of IGF-1R. In short, the current study found that propofol affected the biological activity of IGF-1, which laid the foundation for related research. |
| تدمد: | 1029-2292 0897-7194 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9dded8d8d3b01bdd97dce4b8c49ce2 https://doi.org/10.1080/08977194.2022.2150189 |
| رقم الأكسشن: | edsair.doi.dedup.....aa9dded8d8d3b01bdd97dce4b8c49ce2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 10292292 08977194 |
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